Here’s the structured profile for Clarithromycin Tablet 250 mg 👇
💊 Clarithromycin Tablet 250 mg
📘 Description:
- Clarithromycin is a macrolide antibiotic (semi-synthetic derivative of erythromycin).
- It inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit.
- Has bacteriostatic activity (can be bactericidal at high concentrations).
📄 Prescription / Indications:
- Respiratory tract infections → bronchitis, pneumonia, sinusitis, pharyngitis, tonsillitis.
- Skin & soft tissue infections → cellulitis, impetigo, erysipelas.
- Helicobacter pylori infection (part of triple/quadruple therapy for peptic ulcer).
- Mycobacterial infections → Mycobacterium avium complex (MAC).
- Otitis media in children (alternative when penicillin not suitable).
🌿 Nature / Drug Class:
- Antibiotic – Macrolide class
- Bacteriostatic (dose-dependent bactericidal action possible)
✅ Advantages:
- More stable & better oral absorption than erythromycin.
- Longer half-life → allows twice-daily dosing.
- Effective against atypical bacteria (Mycoplasma, Chlamydophila, Legionella).
- Useful in H. pylori eradication regimens.
⚠️ Precautions:
Contraindications:
- Hypersensitivity to macrolides.
- Concomitant use with drugs that cause QT prolongation.
- Patients with history of torsades de pointes or severe arrhythmia.
Use with caution in:
- Liver impairment (metabolized in liver).
- Renal impairment (dose adjustment in severe cases).
- Patients on CYP3A4 substrates (risk of drug interactions).
Adverse Effects:
- GI upset – nausea, diarrhea, abdominal pain.
- Headache, altered taste.
- Rare: QT prolongation, hepatotoxicity, cholestatic jaundice.
- Risk of drug interactions (warfarin, statins, carbamazepine, theophylline).
💊 Dosage (Adults):
- Typical: 250 mg every 12 hours.
- Severe infections: 500 mg every 12 hours.
- H. pylori regimen: 500 mg twice daily (with amoxicillin + PPI).
- Duration: usually 7–14 days.
📦 Common Packaging:
- Blister strips of 10 tablets (250 mg each).
- Hospital packs available.
❄️ Storage Conditions:
- Store below 25°C, protected from light and moisture.
- Keep out of reach of children.