Here is the detailed profile for:
💉 Ceftriaxone Powder for Injection 500 mg
📘 Description:
Ceftriaxone 500 mg is a broad-spectrum, third-generation cephalosporin antibiotic provided as a sterile powder for intravenous (IV) or intramuscular (IM) injection. It offers once-daily dosing due to its long half-life and is widely used in hospital and outpatient settings.
💊 Prescription / Indications:
Indicated for treatment of moderate to severe infections, including:
- Lower respiratory tract infections (e.g. pneumonia)
- UTIs (Urinary Tract Infections)
- Skin and soft tissue infections
- Meningitis
- Septicemia
- Gonorrhea
- Bone and joint infections
- Intra-abdominal infections (with metronidazole)
- Pre- and post-operative surgical prophylaxis
🩺 Uses:
- Effective against a wide range of Gram-positive and Gram-negative organisms
- Preferred in empiric therapy when the causative pathogen is unknown
- Suitable for hospital-acquired and community-acquired infections
- Frequently used in pediatrics, emergency care, ICUs, and for sexually transmitted infections (STIs)
🌿 Nature:
- Drug Class: Cephalosporin (3rd generation)
- Form: Lyophilized sterile powder
- Route: IV or IM
- Mechanism: Inhibits bacterial cell wall synthesis, causing cell death
✅ Advantages:
- Broad-spectrum coverage
- Long half-life enables once-daily dosing
- Well tolerated and widely available
- Useful for infections of CNS, respiratory, urinary, and genital systems
- Stable in various diluents for hospital use
- Often used in surgical prophylaxis
⚠️ Precautions:
- Avoid in patients allergic to cephalosporins or penicillins
- Avoid mixing with calcium-containing solutions in neonates
- Use cautiously in hepatic/renal dysfunction
- Monitor for signs of hypersensitivity, diarrhea, or superinfection
- Rare risk of gallbladder sludge, especially in children
- Pain at injection site may occur (especially with IM route)
📦 Common Packaging:
- Supplied in glass vials with 500 mg sterile powder
- Single-use vial for IM or IV reconstitution
- Often bundled with sterile water or lidocaine for IM dilution
- Frequently used in emergency kits, hospital wards, and operation theatres
❄️ Storage:
- Store below 25°C in a cool, dry place
- Protect from light and moisture
- After reconstitution:
- Use immediately OR
- Store at 2–8°C and use within recommended period
- Do not freeze reconstituted solution
- Keep out of reach of children