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💉 Ceftriaxone Powder for Injection 250 mg
📘 Description:
Ceftriaxone 250 mg is a third-generation cephalosporin antibiotic, presented as a sterile lyophilized powder for intravenous (IV) or intramuscular (IM) administration. It is known for its broad-spectrum bactericidal activity and long half-life, allowing once-daily dosing in many cases.
💊 Prescription / Indications:
Used to treat a wide variety of infections, including:
- Respiratory tract infections (e.g. pneumonia, bronchitis)
- Urinary tract infections (UTIs)
- Skin and soft tissue infections
- Bacterial meningitis
- Intra-abdominal infections
- Septicemia
- Gonorrhea
- Surgical prophylaxis
- Bone and joint infections
🩺 Uses:
- Effective against both Gram-positive and Gram-negative organisms
- Often used in hospital and outpatient parenteral therapy
- Suitable for empiric treatment where organism is unknown
- May be used in combination with other antibiotics (e.g. metronidazole for anaerobic coverage)
🌿 Nature:
- Class: Cephalosporin (3rd generation)
- Form: Lyophilized powder
- Route: IV or IM injection
- Action: Inhibits bacterial cell wall synthesis → causes cell lysis (bactericidal)
✅ Advantages:
- Broad spectrum, covers a wide range of pathogens
- Long half-life allows once-daily dosing in most cases
- Effective against many β-lactamase-producing bacteria
- Good CNS penetration — useful for meningitis
- Convenient for outpatient parenteral therapy (OPAT)
⚠️ Precautions:
- Contraindicated in individuals with known cephalosporin allergy
- Caution in patients with penicillin allergy (cross-reactivity may occur)
- Avoid calcium-containing solutions in neonates (risk of precipitate formation)
- Adjust dose in hepatic and/or renal impairment
- Possible side effects: diarrhea, rash, eosinophilia, thrombocytosis, injection site pain
- Risk of biliary sludge or gallbladder pseudolithiasis in children
📦 Common Packaging:
- Supplied in glass vials containing 250 mg of sterile powder
- For single-dose use
- Common in hospital kits, surgical prophylaxis, pediatric settings
- Reconstituted with sterile water, normal saline, or lidocaine (for IM use)
❄️ Storage:
- Store in a cool, dry place, below 25°C
- Protect from light and moisture
- After reconstitution:
- Use immediately, or
- Store in refrigerator (2–8°C) and use within recommended timeframe
- Do not freeze reconstituted solution
- Keep out of reach of children