Here is the detailed profile for:
💉 Ceftriaxone Powder for Injection 2000 mg (2 g)
📘 Description:
Ceftriaxone 2 g is a broad-spectrum third-generation cephalosporin antibiotic, available as a sterile lyophilized powder for IV (intravenous) use. It is typically used in hospital settings for serious or deep-seated infections where higher doses are required.
💊 Prescription / Indications:
Ceftriaxone 2 g is used for:
- Severe bacterial infections (e.g., sepsis, pneumonia, meningitis)
- Hospital-acquired infections
- Central nervous system infections
- Infective endocarditis
- Peritonitis or abdominal infections
- Empirical treatment in febrile neutropenia
- Surgical prophylaxis (pre-operative, especially for major abdominal surgeries)
- Sometimes used in gonorrhea or pelvic inflammatory disease (PID) when higher doses are required
🩺 Uses:
- Appropriate when high tissue or CSF concentrations are needed
- Commonly administered in ICUs, neuro units, and post-op wards
- Can be used once or twice daily, depending on the infection and patient status
🌿 Nature:
- Drug Class: Cephalosporin antibiotic (3rd generation)
- Form: Lyophilized sterile powder
- Route: Intravenous injection (IM route not suitable for 2 g dose)
- Action: Bactericidal – inhibits bacterial cell wall synthesis
✅ Advantages:
- Effective against a wide range of Gram-positive and Gram-negative bacteria
- Long half-life – allows once-daily dosing in many infections
- Penetrates well into tissues and cerebrospinal fluid (CSF)
- Lower resistance when used correctly
- Suitable for monotherapy in many serious infections
⚠️ Precautions:
- Hypersensitivity: Avoid in patients with cephalosporin or penicillin allergy
- Not to be mixed or infused simultaneously with calcium-containing IV fluids
- In renal or hepatic impairment, monitor and adjust if needed
- Possible side effects:
- Diarrhea
- Rash
- Biliary sludge (especially in prolonged pediatric use)
- Local pain or thrombophlebitis at IV site
- Use with caution in neonates (especially those with hyperbilirubinemia)
📦 Common Packaging:
- Glass vial containing 2 g sterile powder
- Usually provided without diluent; reconstituted with sterile water for injection or IV-compatible fluids
- Labeled for single-dose use only
❄️ Storage:
- Store the unopened vial below 25°C, protected from light
- Reconstituted solution:
- Use immediately if possible
- If refrigerated (2–8°C), use within 24 hours (check manufacturer instructions)
- Do not freeze reconstituted solution
- Keep out of reach of children