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💉 Ceftriaxone Powder for Injection 1000 mg (1 g)
📘 Description:
Ceftriaxone 1000 mg is a broad-spectrum third-generation cephalosporin antibiotic, presented as a sterile lyophilized powder for intravenous (IV) or intramuscular (IM) use. It is commonly used for moderate to severe bacterial infections across multiple organ systems.
💊 Prescription / Indications:
Prescribed for a wide variety of infections, including:
- Community-acquired and hospital-acquired pneumonia
- Urinary tract infections (UTIs)
- Meningitis (bacterial)
- Septicemia (blood infections)
- Intra-abdominal infections (usually with metronidazole)
- Bone and joint infections
- Pelvic inflammatory disease
- Gonorrhea
- Surgical prophylaxis
🩺 Uses:
- Empiric treatment of infections before organism identification
- Used in ICU, emergency care, and surgical wards
- Common in pediatric, adult, and geriatric populations
- Also used for long-term infections like osteomyelitis and endocarditis
🌿 Nature:
- Drug Class: Cephalosporin (3rd generation)
- Form: Sterile powder
- Route: IV or IM
- Mechanism of Action: Inhibits bacterial cell wall synthesis leading to cell death (bactericidal)
✅ Advantages:
- Once-daily dosing (due to long half-life)
- Broad-spectrum activity against Gram-positive and Gram-negative organisms
- Well tolerated in most populations
- Effective in CNS infections like meningitis
- Used both as curative and preventive (prophylactic) therapy
- Minimal resistance when used appropriately
⚠️ Precautions:
- Allergy warning: Avoid in those allergic to cephalosporins or penicillins
- Do not co-administer with calcium-containing IV solutions (especially in neonates)
- Monitor for superinfections, diarrhea, or fungal overgrowth with long-term use
- May cause gallbladder sludge or pseudolithiasis (especially in children)
- Reduce dose in renal or hepatic impairment
- IM injections may be painful — often reconstituted with lidocaine
📦 Common Packaging:
- Supplied as glass vial containing 1 g sterile powder
- For single use after reconstitution
- Often provided with diluent (sterile water or lidocaine)
- Packed in hospital kits or single-dose trays
❄️ Storage:
- Store below 25°C
- Protect from light and moisture
- After reconstitution:
- Use immediately OR
- Store at 2–8°C (refrigerator) and use within specified time
- Do not freeze reconstituted solution
- Keep out of reach of children