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💉 Cefotaxime Powder for Injection 1000 mg (1 g)
📘 Description:
Cefotaxime 1000 mg is a third-generation cephalosporin antibiotic formulated as a sterile lyophilized powder for intravenous (IV) or intramuscular (IM) injection. It is used in the treatment of moderate to severe infections caused by susceptible bacteria.
💊 Prescription / Indications:
Cefotaxime 1 g is indicated for:
- Severe respiratory tract infections (e.g. hospital-acquired pneumonia)
- Sepsis and bacteremia
- Urinary tract infections, especially pyelonephritis
- Gynecologic infections, including pelvic inflammatory disease
- Intra-abdominal infections (e.g. peritonitis)
- Meningitis
- Skin and soft tissue infections
- Bone and joint infections
- Prophylaxis in surgical procedures (especially abdominal, urologic, or gynecologic)
🩺 Uses:
- Broad-spectrum bactericidal agent
- Active against Gram-positive and Gram-negative bacteria
- Used as part of empirical therapy in hospitalized or ICU patients
🌿 Nature:
- Drug class: Cephalosporin (β-lactam antibiotic)
- Form: Sterile lyophilized powder
- Route: IV/IM injection
- Mechanism: Inhibits bacterial cell wall synthesis → leads to cell lysis
✅ Advantages:
- Strong and rapid antibacterial activity
- Effective even in serious systemic infections
- Good CNS penetration — useful in meningitis
- Can be combined with other antibiotics (e.g. metronidazole) in polymicrobial infections
- Well tolerated in most patients
⚠️ Precautions:
- Contraindicated in patients allergic to cephalosporins or β-lactams
- Adjust dose in patients with renal impairment
- Long-term use may lead to superinfections (e.g., fungal overgrowth)
- Hypersensitivity reactions can occur — test if history of penicillin allergy
- Use under medical supervision only
📦 Common Packaging:
- Glass vial containing 1000 mg (1 g) of sterile powder
- Often packed in hospital packs or individually
- Administered after reconstitution with sterile water or suitable diluent
❄️ Storage:
- Store below 25°C in a dry place
- Protect from light and moisture
- Use the reconstituted solution immediately or within specified time if stored in refrigeration
- Do not freeze
- Keep out of reach of children