Carbimazole Tablet 10 mg

💊 Carbimazole Tablet 10 mg – As Licensed

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📄 **Description:

Carbimazole** is an antithyroid medication used to treat hyperthyroidism by suppressing the excessive production of thyroid hormones (T3 and T4). It is a prodrug that is converted in the body to the active form, methimazole.

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🧾 Prescription / Use:

• Indications:
  • Graves’ disease
  • Toxic multinodular goitre
  • Preoperative control before thyroidectomy
  • Preparation before radioactive iodine therapy
• Dosage:
  • Initial dose: 20–40 mg/day in divided doses
    (i.e., 2–4 tablets of 10 mg)
  • Maintenance dose: 5–15 mg/day
  • Doses may be reduced based on thyroid hormone levels
  • Treatment typically continued for 12–18 months
• Route: Oral

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🔬 Nature:

• Category: Antithyroid drug (Thionamide class)
• Form: Oral tablet
• Mechanism: Inhibits thyroid peroxidase enzyme, reducing production of T3 and T4 hormones
• Active Metabolite: Methimazole

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🌟 Advantages:

• Non-invasive therapy for overactive thyroid
• Allows time for spontaneous remission
• Effective in both adults and children
• Can be used safely during pregnancy (with caution)

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📦 Common Packaging:

• Tablet strength: 10 mg
• Typically packed in blister strips of 10 or 15 tablets
• Outer box with batch no., expiry date, and manufacturer name

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🧊 Storage:

• Store at room temperature (below 25°C)
• Keep away from moisture, heat, and light
• Store in the original package

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⚠️ Precautions:

Contraindications:

• Allergy to carbimazole or thionamides
• History of agranulocytosis
• Severe liver dysfunction

Use with Caution:

• Pregnancy: Avoid high doses in the first trimester (may switch to PTU)
• Breastfeeding: Can be used with caution and monitoring
• Monitor: CBC, liver function, and thyroid function regularly

Common Side Effects:

• Nausea, headache
• Rashes, itching
• Altered taste

Serious Risks:

• Agranulocytosis (low white cell count) – medical emergency
• Liver injury
• Vasculitis (inflammation of blood vessels)

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👩‍⚕️ Patient Advice:

• Do not stop medication suddenly without doctor’s advice
• Take with or after food to reduce stomach upset
• Report immediately if you develop:
  • Sore throat
  • Fever
  • Mouth ulcers
• Regular blood and thyroid tests are essential
• Avoid contact with infections due to possible low immunity