Here is a comprehensive overview of Budesonide Inhalation 100 mcg/dose (MDI/DPI) — without any brand names and in a professional medical format:
💨 Budesonide Inhalation 100 mcg/dose (MDI/DPI)
(Metered Dose Inhaler / Dry Powder Inhaler)
✅ DESCRIPTION
Budesonide is an inhaled corticosteroid used for maintenance treatment of asthma and chronic obstructive pulmonary disease (COPD). It works by reducing airway inflammation, thereby decreasing symptoms like wheezing, breathlessness, and cough.
🧪 FORMULATION
- Strength: 100 micrograms of Budesonide per dose
- Form:
- MDI (Metered Dose Inhaler): uses propellant to deliver aerosol spray
- DPI (Dry Powder Inhaler): breath-actuated powder inhaler
- Excipients may include propellants (in MDI), lactose (in DPI)
🌿 NATURE
- Class: Inhaled Glucocorticoid (ICS)
- Mechanism: Anti-inflammatory; inhibits release of inflammatory mediators and cytokines in the lungs
- Onset: Delayed (several hours to days); not for acute relief
📌 USES
- Asthma: maintenance therapy for persistent asthma
- COPD: as part of combination therapy in moderate to severe cases
- Allergic bronchitis or airway hyperresponsiveness (off-label in some cases)
🌟 ADVANTAGES
- Direct lung delivery with minimal systemic effects
- Reduces frequency of exacerbations
- Long-term control of symptoms
- May reduce or eliminate need for oral corticosteroids
- Safe in children (with proper monitoring)
⚠️ PRECAUTIONS
Common Side Effects:
- Hoarseness of voice (dysphonia)
- Oral thrush (candidiasis)
- Cough, throat irritation
- Headache
Serious but rare:
- Growth suppression in children (long-term use)
- Systemic corticosteroid effects if overdosed
Usage Cautions:
- Not a rescue inhaler (no role in acute asthma attacks)
- Rinse mouth after use to avoid oral fungal infections
- Use with a spacer device (in MDI) for better delivery and reduced side effects
❌ CONTRAINDICATIONS
- Known hypersensitivity to budesonide or lactose (in DPI)
- Acute severe asthma attack (use short-acting beta-agonist instead)
- Active pulmonary tuberculosis (without supervision)
🕒 DOSAGE GUIDELINES
- Adults & Adolescents: 100–400 mcg twice daily
- Children (above 6 years): 100 mcg once or twice daily, depending on severity
- Dose adjusted based on response and control
Note: Always use as prescribed by a physician and follow inhaler technique properly.
🤝 DRUG INTERACTIONS
- Strong CYP3A4 inhibitors (e.g., ketoconazole) may increase systemic budesonide levels
- May interact with other inhaled steroids or immunosuppressants
🧊 STORAGE
- Store at below 30°C, away from moisture, heat, and direct sunlight
- DPI: Keep dry, do not wash
- MDI: Keep canister tightly closed; avoid puncturing or incinerating