Here is the complete profile for:
💉 Benzathine Benzylpenicillin Powder for Injection – 24,00,000 Units
🧪 Nature / Drug Class
- Long-acting natural penicillin
- Beta-lactam antibiotic, bactericidal
- Depot injection for sustained effect over 2–4 weeks
🩺 Purpose / Indications
Used to treat and prevent infections including:
- Latent and late syphilis (single dose)
- Congenital syphilis (infant dose adjustments may vary)
- Streptococcal infections – pharyngitis, rheumatic fever prophylaxis
- Yaws, Bejel, Pinta (endemic treponematoses)
- Skin/soft tissue infections
⚙️ Advantages
✔️ Single-dose treatment in some STIs
✔️ Long-acting → less frequent dosing (2–4 weeks coverage)
✔️ Good for mass prophylaxis programs
✔️ Ensures adherence in chronic prophylaxis (e.g. rheumatic fever)
💊 Dosage & Administration
- Typical adult dose: 2.4 million units IM once
- Route: Deep intramuscular (IM) injection only
- Not for IV or subcutaneous use
Reconstitution:
- Reconstitute with 4–5 mL of sterile water for injection
- Shake vigorously until a uniform suspension is obtained
📦 Common Packaging
- Glass vial containing sterile powder with 2.4 million units
- May be supplied with sterile diluent separately
- Single-dose vial
⚠️ Patient Advice / Precautions
- Do NOT inject IV – may cause sudden death
- Test for penicillin allergy before use
- Use cautiously in renal impairment
- Inject deep into gluteal muscle to reduce local reaction
- Use in pregnancy is considered safe (Category B)
- Watch for hypersensitivity or anaphylaxis
💢 Common Side Effects
- Injection site pain or swelling
- Fever, rash, itching
- Hypersensitivity reactions, including rare anaphylaxis
- Rare: Serum sickness, neurovascular issues if improperly injected
🧊 Storage
- Store below 25°C
- Keep dry, away from sunlight
- Do not freeze
- Use immediately after reconstitution