Here is the full detail for Bedaquiline Tablet 100 mg:
💊 Bedaquiline Tablet 100 mg
🧪 Generic Name:
Bedaquiline Fumarate
📦 Strength & Form:
- Tablet: 100 mg of Bedaquiline base
- Oral administration
🩺 Indications / Uses:
Used exclusively for:
- Multidrug-Resistant Tuberculosis (MDR-TB)
- In combination with other anti-TB medicines
It is not used alone and only under specialist supervision within national TB programs.
⚖️ Dosage (Adults):
As per WHO and national TB guidelines:
- Weeks 1–2:
400 mg once daily (i.e. 4 tablets of 100 mg) - Weeks 3–24:
200 mg three times per week (e.g. Monday, Wednesday, Friday)
Total duration: 24 weeks (6 months)
⚠️ Precautions:
- QT prolongation: Monitor ECG regularly
- Use with caution with QT-prolonging drugs
- Hepatotoxicity risk → monitor LFTs
- Must be taken with food for better absorption
🚫 Contraindications:
- Hypersensitivity to Bedaquiline
- History of arrhythmia or prolonged QTc
💥 Common Side Effects:
- Nausea, joint pain
- Headache
- Increased liver enzymes
- Dizziness
- QT prolongation on ECG
💡 Important Notes:
- Use only under DOTS+ or PMDT programs
- Requires monitoring ECG, LFT, and electrolytes
- Not recommended in pregnancy, children <18 yrs, or non-TB indications