Here is the detailed profile for:
💉 Azithromycin Powder for Injection 500 mg
📘 Description:
Azithromycin 500 mg injection is a parenteral macrolide antibiotic used for systemic bacterial infections, particularly in moderate to severe cases or when oral therapy is not feasible. It is reconstituted into a solution and administered intravenously (IV).
💊 Prescription / Indications:
Used for the treatment of infections caused by susceptible bacteria, including:
- Community-acquired pneumonia (CAP)
- Pelvic inflammatory disease (PID)
- Mycobacterial infections (in immunocompromised patients)
- Severe respiratory tract infections
- Skin and soft tissue infections
- As part of combination therapy in enteric fever or STDs
🌿 Nature / Drug Class:
- Macrolide antibiotic
- Bacteriostatic (inhibits protein synthesis)
- Selectively binds to the 50S ribosomal subunit
✅ Advantages:
- Effective in once-daily dosing
- Alternative for patients allergic to penicillins
- Good tissue penetration, long half-life
- Can be switched to oral formulation after stabilization
- Effective against atypical pathogens like Mycoplasma, Chlamydia
⚠️ Precautions:
- Administer only as IV infusion, not IM or IV bolus
- Reconstitute with sterile water and dilute in appropriate infusion fluid
- Use with caution in:
- Hepatic impairment
- History of QT prolongation / cardiac arrhythmia
- Electrolyte disturbances
- Monitor for allergic reactions, thrombophlebitis, or GI upset
- Avoid mixing with other drugs in the same IV line
📦 Common Packaging:
- Glass vial containing 500 mg azithromycin (as dihydrate)
- Supplied as lyophilized powder
- Requires reconstitution before use
- Comes with or without diluent depending on manufacturer
❄️ Storage:
- Store below 25°C, protect from light and moisture
- Once reconstituted:
- Use immediately or within 24 hours (if stored refrigerated)
- Do not freeze
- Discard any unused portion