Here is a detailed overview of Atropine Eye Drops 1%:
✅ DESCRIPTION
Atropine Sulfate 1% Ophthalmic Solution is a muscarinic receptor antagonist used to dilate the pupil (mydriasis) and paralyze accommodation (cycloplegia). It is commonly used in eye examinations, to treat uveitis, and in pediatric ophthalmology (e.g., amblyopia treatment).
🧪 FORMULATION
- Active Ingredient: Atropine Sulfate 1% (10 mg/mL)
- Preservative: Benzalkonium chloride (typically 0.01%)
- Other Excipients:
- Sodium chloride
- Hydrochloric acid/sodium hydroxide (pH adjustment)
- Purified water
- Form: Sterile ophthalmic solution
🌿 NATURE
- Type: Anticholinergic (muscarinic blocker)
- Class: Mydriatic / Cycloplegic agent
- Mechanism of Action:
Blocks muscarinic receptors in the iris sphincter and ciliary muscle → leads to pupil dilation and loss of accommodation
💊 USES
- Diagnostic:
- Fundoscopy and refraction testing in children and adults
- Therapeutic:
- Uveitis or iritis (to relieve pain and prevent synechiae)
- Amblyopia (lazy eye) treatment in children
- Post-surgical management to reduce inflammation and spasms
- Off-label / Other uses:
- Myopia control (low-dose atropine preferred, e.g., 0.01%)
- Ciliary spasm or photophobia
🌟 ADVANTAGES
- Long-acting mydriasis and cycloplegia (7–14 days)
- Useful for deep ocular inflammation
- Reliable cycloplegic for accurate refraction in children
- Once or twice daily dosing depending on condition
⚠️ PRECAUTIONS
- Common Side Effects:
- Blurred vision
- Sensitivity to light (photophobia)
- Eye irritation or stinging
- Systemic Side Effects (especially in children):
- Dry mouth
- Flushed skin
- Rapid heartbeat (tachycardia)
- Restlessness, irritability
- Fever (anticholinergic toxicity — rare but serious)
- Contraindications:
- Narrow-angle glaucoma
- Hypersensitivity to atropine
- Use with caution in:
- Infants and young children (risk of systemic absorption – use punctal occlusion)
- Elderly or those with prostatic hypertrophy or cardiac conditions
- Contact Lens Users:
Avoid during treatment.
🧊 STORAGE
- Store at 15°C to 25°C (room temperature)
- Protect from light and moisture
- Do not freeze
- Keep the bottle tightly closed
- Discard 28 days after opening
- Keep out of reach of children
- Use only under medical supervision