💉 Atracurium Injection 10 mg/mL
📘 **Description:
Atracurium Besylate Injection 10 mg/mL** is a non-depolarizing neuromuscular blocking agent used during general anesthesia to induce skeletal muscle relaxation, particularly for endotracheal intubation, mechanical ventilation, and surgical procedures.
It is a benzylisoquinolinium compound that blocks acetylcholine at neuromuscular junctions, leading to temporary paralysis of skeletal muscles.
🔬 Formulation:
- Active Ingredient: Atracurium Besylate
- Concentration: 10 mg/mL
- Form: Clear, colorless to pale yellow sterile solution
- Route of Administration: Intravenous (IV) only
- Packaging: Vials or ampoules (2.5 mL, 5 mL, 10 mL)
🧪 Nature / Mechanism of Action:
- Class: Non-depolarizing neuromuscular blocker
- Mechanism: Competes with acetylcholine for nicotinic receptors at the motor end-plate, preventing depolarization
- Onset: 2–3 minutes
- Duration: 20–35 minutes
- Metabolism: Undergoes Hofmann elimination (organ-independent metabolism), making it safer for use in renal or hepatic impairment
🩺 Indications / Uses:
- ✅ Muscle relaxation during:
- General anesthesia for surgery
- Endotracheal intubation
- Mechanical ventilation in ICU
- ✅ As an adjunct to anesthesia in short to intermediate procedures
- ✅ Suitable for patients with renal or liver impairment due to unique metabolism
✅ Advantages:
- Intermediate duration of action
- Organ-independent metabolism (Hofmann elimination)
- Predictable onset and recovery
- Minimal cardiovascular effects (low histamine release at normal doses)
- Useful in renal or hepatic dysfunction
⚠️ Precautions:
- Must be administered only by trained professionals with airway and ventilatory support available
- Can cause histamine release at high doses → hypotension, flushing, bronchospasm
- Use caution in:
- Asthma or reactive airway disease
- Neuromuscular disorders (e.g. myasthenia gravis)
- Electrolyte imbalances (esp. hypokalemia or hypocalcemia)
- No sedative or analgesic effects → should be used with adequate anesthesia
💡 Monitoring:
- Use peripheral nerve stimulator to monitor depth of neuromuscular block
- Ensure adequate sedation and analgesia during use
- Watch for return of spontaneous respiration before extubation
📦 Storage:
- Store at 2–8°C (Refrigerated)
- Do not freeze
- Protect from light
- Use within recommended shelf life once opened