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๐ Ampicillin Powder for Injection 500 mg
๐งช Nature / Drug Class
- Ampicillin is a ฮฒ-lactam antibiotic in the aminopenicillin group
- Broad-spectrum, bactericidal activity against Gram-positive and Gram-negative bacteria
๐ฉบ Purpose / Indications
Used in treatment of moderate to severe infections, including:
- Respiratory tract infections (e.g. bronchitis, pneumonia)
- Urinary tract infections (UTI)
- Gastrointestinal infections (e.g. typhoid, enteric fever)
- Septicemia
- Bacterial meningitis
- Skin and soft tissue infections
- Perinatal infections
โ๏ธ Advantages
โ๏ธ Active against Listeria, Streptococcus, Enterococcus, and some Gram-negative bacilli
โ๏ธ Well tolerated
โ๏ธ Commonly used in neonatal sepsis and meningitis protocols
โ๏ธ Often part of empirical therapy in hospitals
๐ Dosage & Administration
- Adult dose: 500 mg every 6 hours, can be increased depending on infection severity
- Route:
- Intramuscular (IM)
- Intravenous (IV) injection or infusion
- Pediatric/neonatal dose: Adjust according to body weight and age
- Reconstitution:
- For IM: Dissolve 500 mg in 1.5โ2 mL sterile water
- For IV: Dissolve 500 mg in 5 mL sterile water, inject slowly over 3โ5 minutes
- For IV infusion: Dilute in compatible IV fluids (e.g., NS, D5W)
๐ฆ Common Packaging
- Vial containing sterile powder with 500 mg Ampicillin
- Supplied with or without sterile water for injection
โ ๏ธ Patient Advice / Precautions
- Screen for penicillin allergy (can cause severe hypersensitivity)
- Monitor renal function in prolonged use or high doses
- Adjust dose in renal impairment
- May interfere with oral contraceptives
๐ข Common Side Effects
- Pain at injection site
- Nausea, vomiting, diarrhea
- Rash or allergic reaction
- Rare:
- Anaphylaxis
- Seizures (in high doses or renal failure)
- Superinfection (e.g. candidiasis)
๐ง Storage
- Store powder below 25ยฐC, away from light and moisture
- After reconstitution:
- Use immediately
- Discard unused solution
- Do not freeze