Here is the complete profile for:
💉 Ampicillin Powder for Injection 1000 mg (1 g)
🧪 Nature / Drug Class
- Ampicillin: β-lactam aminopenicillin antibiotic
- Broad-spectrum and bactericidal action
- Belongs to the penicillin group
🩺 Purpose / Indications
Used in moderate to severe infections caused by susceptible bacteria, including:
- Respiratory tract infections (pneumonia, bronchitis)
- Urinary tract infections (UTIs)
- Bacterial meningitis
- Gastrointestinal infections (e.g., enteric fever, shigellosis)
- Septicemia / Bloodstream infections
- Peritonitis
- Skin and soft tissue infections
- Post-surgical prophylaxis
⚙️ Advantages
✔️ Effective against many Gram-positive and Gram-negative organisms
✔️ First-line for Listeria monocytogenes and Enterococcus faecalis infections
✔️ Can be used in combination with other antibiotics (e.g., gentamicin) for synergy
✔️ Suitable for neonatal and pediatric use with dose adjustment
💊 Dosage & Administration
- Adults: 1 g IV/IM every 6 hours, based on infection severity
- Neonates / Pediatrics: Dosage based on weight and age
- Route:
- Intravenous (IV) injection or infusion
- Intramuscular (IM)
Reconstitution:
- For IV bolus: Reconstitute 1 g with 10 mL of sterile water
- For IV infusion: Dilute further in 50–100 mL of a compatible IV fluid
- For IM injection: Reconstitute with 3.5 mL of sterile water
📦 Common Packaging
- Single-use vial with sterile powder
- Strength: 1 g (1000 mg) Ampicillin
- May be supplied with sterile water for injection (optional)
⚠️ Patient Advice / Precautions
- Ask about penicillin or β-lactam allergies before use
- Use cautiously in renal impairment — adjust dosage accordingly
- Monitor for superinfection during prolonged therapy
- May reduce efficacy of oral contraceptives
💢 Common Side Effects
- Local pain / inflammation at injection site
- Rash, hypersensitivity reactions
- Gastrointestinal upset: diarrhea, nausea
- Rare:
- Anaphylaxis
- Clostridioides difficile-associated diarrhea
- Seizures (in renal impairment or high doses)
🧊 Storage
- Unreconstituted vials: Store below 25°C, protect from moisture/light
- Reconstituted solution:
- Use immediately after preparation
- Do not freeze
- Discard unused portion after use