Amphotericin B c) Liposomal Amphotericin BInjection 50 mg

💉 Amphotericin B (c) Liposomal Amphotericin B – Injection 50 mg

---

💊 Description:

1. Liposomal Amphotericin B is a lipid-based formulation where Amphotericin B is encapsulated in liposomes (tiny vesicles).
2. It is presented as a sterile, lyophilized powder, to be reconstituted and given via intravenous infusion.
3. Each vial contains 50 mg of Amphotericin B, embedded in liposomes composed of phospholipids and cholesterol.
4. Liposomal form is specifically engineered to reduce toxicity and improve targeting of infected tissues.
5. It is a high-cost, high-efficacy antifungal for serious systemic fungal infections.

---

🌿 Nature:

1. It is a polyene antifungal agent, designed as a liposome-encapsulated formulation.
2. The liposomes enhance selective delivery to fungal-infected cells while sparing human cells.
3. Administered via slow intravenous infusion, not intended for IM or IV bolus.
4. Known for its low immunogenicity and improved patient tolerability.
5. Due to its liposomal nature, it distributes well into RES tissues and crosses barriers like the blood-brain barrier more effectively.

---

✅ Advantages:

1. Significantly reduced nephrotoxicity compared to conventional Amphotericin B.
2. Better tolerance during infusion – fewer chills, rigors, and fever.
3. Allows higher dosing with fewer adverse effects, improving efficacy.
4. Improved drug distribution to infected tissues, especially in deep mycoses.
5. Preferred antifungal for immunocompromised patients, including neonates and transplant patients.

---

🩺 Uses:

1. Treatment of life-threatening systemic fungal infections like aspergillosis, cryptococcosis, and mucormycosis.
2. Visceral leishmaniasis, especially in HIV patients or where sodium stibogluconate fails.
3. Empiric therapy for febrile neutropenic patients unresponsive to broad-spectrum antibiotics.
4. Prophylaxis and treatment in patients undergoing hematopoietic stem cell transplant or chemotherapy.
5. Effective in fungal CNS infections, due to enhanced CNS penetration.

---

❄️ Storage:

1. Store unopened vials at 2–8°C in a refrigerator, protected from light.
2. Do not freeze either the powder or the reconstituted solution.
3. After reconstitution, the solution should be used within 24 hours (if refrigerated).
4. Reconstitute using sterile water for injection only, following the manufacturer’s instructions.
5. Administer via IV infusion over 2+ hours to minimize infusion-related adverse effects.

---