Amphotericin B b) Lipid Amphotericin BInjection 50 mg

💉 Amphotericin B (Lipid Formulation) – Injection 50 mg

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💊 Description:

1. Lipid Amphotericin B is a modified formulation where Amphotericin B is combined with lipids to reduce toxicity.
2. It appears as a white to pale yellow lyophilized cake or powder, reconstituted before IV infusion.
3. The formulation includes lipid complexes or liposomes, depending on the brand (e.g., liposomal, lipid complex, colloidal dispersion).
4. Each vial typically contains 50 mg of Amphotericin B embedded in a lipid matrix.
5. It retains the broad antifungal spectrum of conventional Amphotericin B with improved tolerability.

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🌿 Nature:

1. Polyene macrolide antifungal formulated with phospholipids or cholesterol-based carriers.
2. Designed for IV administration only, with significantly reduced nephrotoxicity.
3. Lipid encapsulation enhances drug delivery to infected tissues, particularly RES organs.
4. Has a longer half-life in tissues due to lipid formulation.
5. These preparations are less immunogenic and better tolerated during infusion.

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✅ Advantages:

1. Lower nephrotoxicity compared to conventional Amphotericin B.
2. Reduced infusion-related reactions (fever, chills, hypotension).
3. Allows higher cumulative doses, beneficial in severe/prolonged infections.
4. Better penetration into reticuloendothelial organs (liver, spleen, lungs).
5. Suitable for use in critically ill and renal-impaired patients.

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🩺 Uses:

1. Systemic fungal infections: candidiasis, aspergillosis, mucormycosis, cryptococcosis.
2. Fungal infections in neutropenic or immunocompromised patients (e.g., transplant, cancer).
3. Treatment of visceral leishmaniasis (especially in HIV co-infected cases).
4. Empirical antifungal therapy in febrile neutropenia when other agents fail.
5. Used in patients with renal dysfunction, where conventional Amphotericin B is contraindicated.

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❄️ Storage:

1. Store the unopened vial at 2–8°C (refrigerator); protect from light.
2. After reconstitution, use within 24 hours if refrigerated; check product guidelines.
3. Do not freeze the reconstituted product.
4. Reconstitute using sterile water for injection as per the manufacturer’s instructions.
5. Administer via slow IV infusion over at least 2 hours to avoid side effects.