Here is the complete overview for:
🧴 Amoxicillin (A) + Clavulanic Acid (B) Dry Syrup
Strength: 125 mg (A) + 31.25 mg (B) per 5 mL
Form: Dry syrup (reconstitutable powder)
Paediatric formulation
🧪 Nature / Drug Class
🔹 Amoxicillin – Broad-spectrum aminopenicillin antibiotic
🔹 Clavulanic Acid – Beta-lactamase inhibitor (protects amoxicillin from enzymatic breakdown)
🔹 Used in combination to treat resistant bacterial infections in children
🩺 Purpose / Indications
Prescribed for bacterial infections in children such as:
- Upper & lower respiratory tract infections (sinusitis, tonsillitis, bronchitis, pneumonia)
- Otitis media
- Skin and soft tissue infections
- Urinary tract infections
- Dental infections
- Some gastrointestinal infections (if bacterial)
⚙️ Advantages
✔️ Effective against beta-lactamase producing bacteria
✔️ Improved efficacy over amoxicillin alone
✔️ Palatable for children (flavored syrup after reconstitution)
✔️ Flexible pediatric dosing based on weight
💊 Dosage & Administration
- Usual pediatric dose: Based on amoxicillin component
- ~20–40 mg/kg/day (mild/moderate)
- Up to 90 mg/kg/day (severe infections)
- Divided in 2–3 doses per day
- Shake well before each use
- Give with food to reduce gastrointestinal upset
- Complete the full course
📦 Common Packaging
- Bottle of powder for reconstitution
- Usually yields 30 mL or 60 mL after reconstitution
- Labelled as 125 mg + 31.25 mg per 5 mL
⚠️ Patient Advice / Precautions
- Complete full course as prescribed
- Discard unused portion after 7 days of reconstitution
- Keep bottle refrigerated (2–8°C) if advised by manufacturer
- Use measuring spoon/syringe – avoid household spoons
- Report diarrhea, rash, or allergic symptoms
💢 Common Side Effects
- Mild:
- Diarrhea, nausea, abdominal cramps
- Skin rash
- Rare:
- Liver enzyme elevation
- Candidiasis
- Hypersensitivity (rash, anaphylaxis)
🧊 Storage
- Before reconstitution: store below 25°C
- After reconstitution:
- Store in refrigerator (as per label)
- Use within 5–7 days
- Do not freeze