Here is the complete information for Amikacin Injection 250 mg/mL:
💉 Amikacin Injection 250 mg/mL
🧪 Generic Name:
Amikacin Sulfate
💊 Form & Strength:
- Injection (solution for IV or IM use)
- Concentration: 250 mg/mL
- Typically available in 2 mL vials or ampoules
→ Total content per vial: 500 mg
📦 Packaging & Storage:
- Sterile, clear glass ampoules/vials
- Amber-colored for light protection (optional)
- Storage: Below 25°C, protected from light
- Do not freeze
📌 Uses / Indications:
Used for treatment of serious infections caused by Gram-negative bacteria:
- Bloodstream infections (septicemia)
- Respiratory tract infections
- Urinary tract infections (UTIs)
- Bone and joint infections
- Skin and soft tissue infections
- Intra-abdominal infections
- Hospital-acquired infections, e.g., pneumonia, post-surgical infections
💉 Administration Route:
- IM (intramuscular) injection directly
- IV (intravenous) infusion: Dilution required
(use 0.9% NaCl or 5% Dextrose as diluent; infuse over 30–60 minutes)
🧮 Typical Dosage:
Dosage depends on age, weight, renal function, and severity of infection
- Adults:
15 mg/kg/day, divided every 12 hours
(e.g., 500 mg twice daily for 60–70 kg adult) - Children:
15–20 mg/kg/day in divided doses - Neonates:
Initial: 10 mg/kg, then 7.5 mg/kg every 12–24 hours
⚠️ Precautions:
- Nephrotoxicity risk – monitor serum creatinine
- Ototoxicity – hearing loss/tinnitus possible
- Monitor blood levels if prolonged use
- Use cautiously in elderly, renal impairment, or neuromuscular disorders
❌ Contraindications:
- Hypersensitivity to aminoglycosides
- Use with caution in myasthenia gravis
💥 Common Side Effects:
- Kidney toxicity (↑ creatinine, oliguria)
- Ear damage (hearing loss, vertigo, tinnitus)
- Local site reaction (pain, swelling IM)
- Rare: Neuromuscular blockade, rash, nausea