Acetylsalicylic acid Tablet 300 mg to 500 mg

1. Description / Prescription

  • Generic Name: Acetylsalicylic Acid
  • Common Name: Aspirin
  • Dosage Form: Oral Tablet
  • Strength Range: 300 mg to 500 mg
  • Route: Oral
  • Prescription Status:
    • Low-dose aspirin (≤150 mg): Often over-the-counter (OTC)
    • Higher doses (300–500 mg): May require a prescription depending on the indication and country regulations

2. Indications

  • 300–500 mg Dose is used for:
    • Pain relief: Headache, toothache, muscle pain, joint pain
    • Fever reduction
    • Anti-inflammatory effects: Arthritis, rheumatic conditions
    • Short-term treatment of cold and flu symptoms
    • Prevention of clot-related conditions (less common; lower doses usually used)

3. Nature of the Medicine

  • Class: Non-Steroidal Anti-Inflammatory Drug (NSAID)
  • Mechanism of Action:
    • Inhibits COX-1 and COX-2 enzymes, reducing prostaglandin synthesis
    • Provides analgesic, antipyretic, anti-inflammatory, and antiplatelet effects

4. Advantages

  • Fast-acting pain and fever relief
  • Multiple forms available: plain, buffered, enteric-coated, dispersible
  • Can be used for both acute and chronic conditions
  • Inexpensive and widely available

5. Common Packaging

  • Tablet Strengths in This Range: 300 mg, 325 mg, 350 mg, 500 mg
  • Form: Plain tablet, dispersible tablet, effervescent tablet, or enteric-coated tablet
  • Pack Sizes: Usually in blister packs of 10, 12, or 15 tablets
  • May be branded as Disprin, Ecosprin, Aspirin, or generics

6. Storage Conditions

  • Store below 25°C
  • Keep away from moisture and in a dry place
  • Avoid heat and direct sunlight
  • Keep tightly closed and out of reach of children

7. Patient Advice

  • Take after food to reduce stomach irritation
  • Do not crush enteric-coated tablets — swallow whole
  • Drink a full glass of water when taking the tablet
  • Do not use with other NSAIDs (e.g., ibuprofen) unless advised
  • Avoid alcohol — increases risk of gastric bleeding
  • Not suitable for children under 16 (risk of Reye’s syndrome)
  • Inform your doctor if you have:
    • Asthma, stomach ulcers, bleeding disorders, kidney or liver problems

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