Here’s the complete profile for Ethambutol Tablet 200 mg 👇
💊 Ethambutol Tablet 200 mg
📘 Description:
- Ethambutol is a first-line antituberculosis medicine.
- Belongs to the antimycobacterial group.
- Acts by inhibiting arabinosyl transferases, enzymes involved in the synthesis of the mycobacterial cell wall (arabinogalactan layer) → this weakens the bacterial cell wall and prevents growth.
📄 Prescription / Indications:
- Used in treatment of tuberculosis (TB), both pulmonary and extrapulmonary TB.
- Always given in combination with other anti-TB drugs (e.g., isoniazid, rifampicin, pyrazinamide).
- Prevents the development of resistance when combined with other drugs.
🌿 Nature / Drug Class:
- Antimycobacterial agent
- Cell wall synthesis inhibitor
✅ Advantages:
- Essential first-line TB drug.
- Effective against both actively dividing and semi-dormant TB bacilli.
- Helps in preventing resistance to other TB drugs like rifampicin and isoniazid.
⚠️ Precautions:
Contraindications:
- Hypersensitivity to ethambutol.
Caution in:
- Optic neuritis or pre-existing eye disease (may worsen).
- Renal impairment – dose adjustment required.
- Pediatric patients <5 years (difficulty in monitoring vision).
Adverse Effects:
- Optic neuritis (dose-related) → blurred vision, decreased visual acuity, red-green color blindness.
- GI upset, rash.
- Peripheral neuropathy (rare).
💊 Dosage (Adults):
- 15–25 mg/kg body weight per day, orally, in single daily dose or divided doses.
- Example: For a 50 kg adult → 750–1200 mg/day (so 200 mg tablets are used in multiples to adjust exact dose).
- Always part of a combination regimen (not used alone).
📦 Common Packaging:
- Tablets 200 mg, 400 mg, 600 mg, 800 mg, 1000 mg (depending on regimen).
- Often included in fixed-dose combinations (FDCs) with other TB drugs.
❄️ Storage:
- Store below 25°C, in a dry place.
- Protect from light and moisture.