Here’s the structured overview for Amikacin Injection 500 mg/mL 👇
💉 Amikacin Injection 500 mg/mL
📘 Description:
- Amikacin is a semi-synthetic aminoglycoside antibiotic derived from kanamycin.
- It works by binding to the 30S ribosomal subunit, inhibiting bacterial protein synthesis → bactericidal effect.
- Active mainly against Gram-negative bacteria, including multidrug-resistant strains.
📄 Prescription / Indications:
- Severe systemic infections: septicemia, bacteremia.
- Complicated UTIs.
- Hospital-acquired and ventilator-associated pneumonia.
- Intra-abdominal infections (peritonitis, post-surgical).
- Bone, joint, skin & soft tissue infections.
- Multidrug-resistant tuberculosis (MDR-TB) as a second-line injectable.
🌿 Nature / Drug Class:
- Aminoglycoside antibiotic
- Bactericidal
✅ Advantages:
- Effective against resistant Gram-negative organisms (Pseudomonas, Acinetobacter, Klebsiella).
- Useful when gentamicin/tobramycin are not effective.
- Valuable component of MDR-TB regimens.
- Concentrated formulation (500 mg/mL) reduces injection volume → more convenient for IM administration.
⚠️ Precautions:
Contraindications:
- Hypersensitivity to aminoglycosides
- Severe renal impairment (unless adjusted/monitored)
Caution in:
- Elderly patients
- Renal impairment → requires dose/interval adjustment
- Concurrent nephrotoxic/ototoxic drugs (vancomycin, amphotericin B, loop diuretics)
Adverse Effects:
- Nephrotoxicity (dose-related, reversible if caught early)
- Ototoxicity (irreversible hearing/vestibular damage possible)
- Injection site pain or phlebitis
- Rare: neuromuscular blockade (especially in myasthenia gravis, with anesthetic agents)
💊 Dosage (Adults):
- 15 mg/kg/day IV or IM in 2–3 divided doses
- e.g., 7.5 mg/kg every 12 hours
- MDR-TB: 15 mg/kg once daily (max 1 g/day)
- Adjust for renal function and monitor creatinine levels regularly.
📦 Common Packaging:
- Vial/ampoule: 500 mg/mL × 1 mL (total 500 mg per vial)
- Administered as:
- Deep IM injection
- IV infusion (diluted before use)
❄️ Storage Conditions:
- Store below 25°C
- Protect from light and freezing
- Single-use vials – discard any unused portion