Here’s the structured overview for Amikacin Injection 250 mg/mL 👇
💉 Amikacin Injection 250 mg/mL
📘 Description:
- Amikacin is a semi-synthetic aminoglycoside antibiotic.
- It acts by binding irreversibly to the 30S ribosomal subunit, blocking bacterial protein synthesis → bactericidal activity.
- Used for severe Gram-negative infections, especially when resistant to other aminoglycosides.
📄 Prescription / Indications:
- Severe systemic infections: septicemia, bacteremia.
- Respiratory tract infections (including hospital-acquired pneumonia).
- Complicated urinary tract infections (UTIs).
- Intra-abdominal infections (peritonitis, post-operative).
- Bone and joint infections.
- Skin and soft tissue infections.
- Multidrug-resistant tuberculosis (MDR-TB) as part of second-line therapy.
🌿 Nature / Drug Class:
- Aminoglycoside antibiotic
- Bactericidal
✅ Advantages:
- Potent activity against multidrug-resistant Gram-negative organisms (e.g., Pseudomonas, Acinetobacter, Klebsiella).
- Often effective when gentamicin/tobramycin are resistant.
- Useful option in MDR-TB treatment regimens.
⚠️ Precautions:
Contraindications:
- Known hypersensitivity to aminoglycosides
- Severe renal failure (unless dose adjusted and monitored)
Caution in:
- Renal impairment → requires dose/interval adjustment
- Elderly patients
- Concurrent nephrotoxic/ototoxic drugs (e.g., vancomycin, amphotericin B, loop diuretics)
Adverse effects:
- Nephrotoxicity (kidney damage, reversible if detected early)
- Ototoxicity (hearing loss, vestibular dysfunction, may be irreversible)
- Injection site pain/phlebitis
- Rare: neuromuscular blockade (risk ↑ in myasthenia gravis, with muscle relaxants)
💊 Dosage (Adults):
- 15 mg/kg/day IV or IM, usually in 2–3 divided doses
- e.g., 7.5 mg/kg every 12 hours
- MDR-TB: 15 mg/kg once daily (max 1 g/day)
- Adjust dosing for renal impairment (monitor creatinine clearance).
👉 The 250 mg/mL strength is commonly supplied in 2 mL (500 mg) vials.
📦 Common Packaging:
- Vials/ampoules: 250 mg/mL × 2 mL (500 mg)
- For IV infusion (diluted) or deep IM injection
❄️ Storage Conditions:
- Store below 25°C
- Protect from light and freezing
- Use immediately after opening (single-use vials)