Here’s the structured overview for Amikacin Injection 100 mg/mL 👇
💉 Amikacin Injection 100 mg/mL
📘 Description:
- Amikacin is a semi-synthetic aminoglycoside antibiotic.
- It works by binding irreversibly to the 30S ribosomal subunit, inhibiting protein synthesis → bactericidal effect.
- Used for serious infections caused by Gram-negative bacteria, especially when resistant to other aminoglycosides.
📄 Prescription / Indications:
- Severe Gram-negative infections (septicemia, bacteremia).
- Respiratory tract infections (e.g., hospital-acquired pneumonia).
- Urinary tract infections (UTIs) – complicated or resistant.
- Intra-abdominal infections (peritonitis, post-surgical).
- Bone and joint infections.
- Skin and soft tissue infections.
- Used in multidrug-resistant tuberculosis (MDR-TB) regimens (second-line drug).
🌿 Nature / Drug Class:
- Aminoglycoside antibiotic
- Bactericidal
✅ Advantages:
- Effective against many multidrug-resistant Gram-negative organisms (e.g., Pseudomonas, Acinetobacter, Klebsiella, Enterobacter).
- Retains activity against some strains resistant to gentamicin or tobramycin.
- Useful in MDR-TB therapy.
⚠️ Precautions:
Contraindications:
- Known hypersensitivity to aminoglycosides
- Patients with severe renal impairment (unless dose adjusted)
Caution in:
- Renal impairment – dose must be adjusted according to creatinine clearance
- Elderly patients
- Concomitant use of other nephrotoxic or ototoxic drugs (e.g., vancomycin, amphotericin B, loop diuretics)
Adverse effects:
- Nephrotoxicity (renal damage)
- Ototoxicity (hearing loss, vestibular dysfunction – sometimes irreversible)
- Injection site pain / phlebitis
- Rare: neuromuscular blockade (especially if given with muscle relaxants or in myasthenia gravis)
💊 Dosage (Adults):
- Usual dose: 15 mg/kg/day IV/IM, given in 2–3 divided doses
- e.g., 7.5 mg/kg every 12 hours
- In MDR-TB: 15 mg/kg once daily (max 1 g/day)
- Adjust dose in renal impairment (extend interval or reduce dose)
👉 The 100 mg/mL strength is typically supplied in 2 mL (200 mg) or 10 mL (1000 mg) vials.
📦 Common Packaging:
- Glass vials/ampoules:
- 100 mg/1 mL, 250 mg/2.5 mL, 500 mg/2 mL, 1000 mg/10 mL
- Supplied for IV infusion or IM injection
❄️ Storage Conditions:
- Store below 25°C
- Protect from light and freezing
- Once opened, use immediately (multi-dose vials follow manufacturer guidance)