Here’s the detailed profile for Dapsone Tablet 50 mg 👇
💊 Dapsone Tablet 50 mg
📘 Description:
- Dapsone is a synthetic sulfone antibiotic.
- It is bacteriostatic against Mycobacterium leprae and some other organisms.
- Has anti-inflammatory and immunomodulatory actions, making it useful in several dermatological disorders.
- A key drug in multidrug therapy (MDT) for leprosy.
📄 Prescription / Indications:
- Leprosy (Hansen’s disease) – as part of WHO MDT (with rifampicin ± clofazimine)
- Dermatitis herpetiformis (chronic blistering skin condition)
- Pneumocystis jirovecii pneumonia (PCP) – prophylaxis or treatment (alternative to co-trimoxazole)
- Toxoplasmosis prophylaxis (alternative use)
🌿 Nature / Drug Class:
- Sulfone class drug
- Antimycobacterial & anti-inflammatory
✅ Advantages:
- Essential part of MDT for leprosy – prevents resistance
- Well-tolerated at low daily doses
- Effective in certain rare dermatological & opportunistic infections
⚠️ Precautions:
Contraindications:
- Hypersensitivity to sulfone drugs
- Severe anemia
Use with caution in:
- G6PD deficiency – risk of hemolysis & methemoglobinemia
- Hepatic or renal impairment
- HIV/AIDS patients (risk of hematological toxicity when used long-term for prophylaxis)
Adverse effects:
- Common: GI upset, headache, dizziness
- Hematological: hemolysis (esp. in G6PD deficiency), anemia, agranulocytosis
- Dermatological: skin rash, pruritus, photosensitivity
- Rare: dapsone hypersensitivity syndrome (fever, rash, hepatitis, lymphadenopathy)
💊 Dosage (Adults):
- Leprosy MDT: 100 mg once daily (self-administered; adults)
- Dermatitis herpetiformis: usually 50–100 mg daily (adjusted by response)
- PCP prophylaxis (alternative): 100 mg daily or 50 mg twice daily
👉 50 mg tablet is mainly used for:
- Children with leprosy (pediatric MDT regimens)
- Adults requiring dose adjustment (e.g., dermatology conditions, prophylaxis)
📦 Common Packaging:
- Tablets: 50 mg and 100 mg
- Supplied in blister packs or bottles
- Included in WHO MDT blister packs for leprosy treatment
❄️ Storage Conditions:
- Store at room temperature (<25°C)
- Protect from light & moisture