Here’s the detailed profile for Clofazimine Capsule 100 mg 👇
💊 Clofazimine Capsule 100 mg
📘 Description:
- Clofazimine is a riminophenazine dye antimycobacterial drug.
- It shows a slow bactericidal effect against Mycobacterium leprae.
- Also has anti-inflammatory action, making it useful in controlling erythema nodosum leprosum (ENL).
- Used as part of multidrug therapy (MDT) for leprosy.
📄 Prescription / Indications:
- Multibacillary leprosy – in combination with rifampicin + dapsone
- Erythema nodosum leprosum (ENL, Type 2 lepra reaction) – acute & chronic management
- Occasionally used off-label in:
- Drug-resistant tuberculosis
- Non-tuberculous mycobacterial infections
🌿 Nature / Drug Class:
- Antimycobacterial agent
- Riminophenazine class
✅ Advantages:
- Key component of WHO-recommended MDT regimen for leprosy
- Anti-inflammatory benefit reduces frequency & severity of lepra reactions
- Helps prevent drug resistance when combined with rifampicin & dapsone
⚠️ Precautions:
Contraindications:
- Known hypersensitivity to clofazimine
Caution in:
- GI disorders (risk of enteritis or obstruction)
- Hepatic impairment
Adverse effects:
- Skin and conjunctival pigmentation (red-brown to black) – very common
- Ichthyosis, dryness, pruritus
- GI issues – abdominal pain, diarrhea, anorexia
- Rare but serious: eosinophilic enteritis, intestinal obstruction, psychiatric symptoms (depression due to cosmetic changes)
💊 Dosage (Adults):
- Leprosy MDT:
- 100 mg once daily (self-administered)
- Plus a supervised monthly dose of 300 mg (given with rifampicin & dapsone as per WHO MDT)
- ENL management: 100–300 mg daily (under supervision, tapered gradually)
📦 Common Packaging:
- Capsules: 50 mg and 100 mg
- Blister strips / bottles
- Supplied in WHO MDT blister packs for leprosy patients
❄️ Storage Conditions:
- Store below 25°C, in a cool, dry place
- Protect from light & moisture