Vancomycin Powder for Injection 500 mg

Here’s the detailed profile for Vancomycin Powder for Injection 500 mg 👇

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💉 Vancomycin Powder for Injection 500 mg

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📘 Description:

• Vancomycin is a glycopeptide antibiotic.
• Administered by intravenous infusion for systemic infections.
• Mechanism of action: Inhibits bacterial cell wall synthesis by binding to the D-Ala-D-Ala terminus of peptidoglycan precursors → prevents cross-linking → bactericidal against Gram-positive organisms.
• The 500 mg vial must be reconstituted and diluted before IV infusion.

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📄 Prescription / Indications:

Indicated for serious Gram-positive infections, especially when resistant to or unsuitable for β-lactams:

• MRSA (Methicillin-resistant Staphylococcus aureus) infections
• Enterococcal infections (including endocarditis)
• Osteomyelitis & septic arthritis
• Hospital-acquired pneumonia
• Septicemia & bacteremia
• Meningitis (as part of combination therapy)
• Skin and soft tissue infections
• Alternative for patients with severe β-lactam allergy

👉 Not absorbed orally → IV route mandatory for systemic therapy.

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🌿 Nature / Drug Class:

• Glycopeptide antibiotic
• Bactericidal (Gram-positive coverage only)

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✅ Advantages:

• Highly effective against MRSA and resistant Gram-positive organisms
• Important in hospital-acquired infections where resistance is common
• Multiple vial strengths (250 mg, 500 mg, 1 g) → allows flexible dosing

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⚠️ Precautions:

Contraindication:

• Hypersensitivity to vancomycin

Use with caution in:

• Renal impairment (dose adjustment + therapeutic drug monitoring required)
• Elderly patients (greater risk of toxicity)
• Concurrent use of nephrotoxic/ototoxic drugs (aminoglycosides, loop diuretics, amphotericin B, cisplatin)

Adverse effects:

• Red man syndrome (flushing, pruritus, hypotension if infused too rapidly)
• Nephrotoxicity
• Ototoxicity (rare, usually with high levels/prolonged use)
• Thrombophlebitis at injection site

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💊 Dosage (Adults):

• 15–20 mg/kg IV every 8–12 hours, individualized
• Adjust dose by renal function and serum trough concentration (target 10–20 µg/mL)

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💉 Administration:

• Reconstitute 500 mg vial with 10 mL sterile water for injection → yields 50 mg/mL solution
• Further dilute in at least 100–250 mL compatible IV fluid (0.9% NaCl or 5% dextrose)
• Infuse over at least 60 minutes (to avoid red man syndrome)

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📦 Common Packaging:

• Glass vials: 500 mg, 1 g, 250 mg (powder for reconstitution)

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❄️ Storage Conditions:

• Store powder vials at room temperature (<25°C), protected from light
• After reconstitution: stable 24 hours at room temp or 7 days refrigerated (2–8°C)

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