Hereβs the detailed profile for Gentamicin Injection 10 mg/mL π
π Gentamicin Injection 10 mg/mL
π Description:
- Gentamicin is an aminoglycoside antibiotic.
- Supplied as solution for injection (10 mg/mL) in ampoules/vials.
- Mechanism: Binds 30S ribosomal subunit, inhibits protein synthesis, and causes misreading of mRNA β bactericidal.
- Active mainly against aerobic Gram-negative bacilli and some Gram-positive organisms (in synergy with other antibiotics).
π Prescription / Indications:
- Severe Gram-negative infections (e.g., E. coli, Klebsiella, Pseudomonas, Proteus)
- Septicemia
- Respiratory tract infections (nosocomial pneumonia)
- Urinary tract infections (complicated/severe)
- Intra-abdominal infections (often with metronidazole/Ξ²-lactams)
- Meningitis (with ampicillin/cefotaxime in neonates)
- Endocarditis (in synergy with penicillin/ampicillin/vancomycin)
- Skin, bone, and soft tissue infections due to susceptible organisms
- Prophylaxis in surgical/ICU settings
πΏ Nature / Drug Class:
- Antibiotic β Aminoglycoside
- Concentration-dependent bactericidal activity
- Post-antibiotic effect against Gram-negative bacteria
β Advantages:
- Rapid bactericidal action against serious Gram-negative infections
- Synergistic activity with Ξ²-lactams or glycopeptides against Gram-positive cocci (e.g., enterococci, staphylococci)
- Useful in life-threatening sepsis and neonatal infections
- Effective in multidrug-resistant Gram-negative infections
β οΈ Precautions:
Contraindications:
- Hypersensitivity to aminoglycosides
Cautions:
- Narrow therapeutic index β requires dose adjustment & monitoring
- Avoid or monitor closely in renal impairment (nephrotoxic risk)
- Risk of ototoxicity (vestibular & auditory damage; irreversible)
- Avoid concurrent use with loop diuretics, vancomycin, amphotericin B, cisplatin (β toxicity)
- Not for long-term use unless essential
Adverse effects:
- Nephrotoxicity (reversible if stopped early)
- Ototoxicity (hearing loss, tinnitus, vertigo β may be irreversible)
- Neuromuscular blockade (rare; caution in myasthenia gravis)
- Injection site pain/irritation
π¦ Common Packaging:
- Ampoules/vials (2 mL, 10 mL) containing 10 mg/mL
- Higher strength preparations also available (40 mg/mL) for adult dosing
π Administration:
- IM injection (common)
- IV infusion (diluted, over 30β60 minutes)
- Dosage: based on weight, renal function, and infection severity (mg/kg basis)
- Therapeutic drug monitoring (TDM) recommended (peak & trough levels)
βοΈ Storage Conditions:
- Store at room temperature (15β25Β°C)
- Protect from light
- Do not freeze