Here’s the detailed medicine profile for Doxycycline Capsule 100 mg 👇
💊 Doxycycline Capsule 100 mg
📘 Description:
- Doxycycline is a tetracycline-class broad-spectrum antibiotic.
- It inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit, preventing aminoacyl-tRNA attachment.
- It is bacteriostatic, but effective against a wide range of Gram-positive, Gram-negative, atypical organisms, and some protozoa.
📄 Prescription / Indications:
- Respiratory tract infections – bronchitis, pneumonia (including atypical pneumonia by Mycoplasma, Chlamydia, Legionella)
- Sexually transmitted infections (STIs) – chlamydia, lymphogranuloma venereum, syphilis (alternative), pelvic inflammatory disease
- Rickettsial infections – typhus, Rocky Mountain spotted fever, scrub typhus
- Malaria prophylaxis & treatment (in combination)
- Cholera, plague, anthrax (including inhalational anthrax post-exposure)
- Skin infections – acne vulgaris, MRSA (community-acquired)
- Periodontal infections
- Leptospirosis and brucellosis (as part of combination therapy)
🌿 Nature / Drug Class:
- Antibiotic – Tetracycline group
- Bacteriostatic
- Broad-spectrum
✅ Advantages:
- Active against many atypical pathogens
- Oral dosing with good bioavailability
- Useful for malaria prophylaxis in travelers
- Preferred drug in rickettsial & zoonotic infections
- Also used for acne due to anti-inflammatory effect
⚠️ Precautions:
Contraindications:
- Children <8 years (causes tooth discoloration & impaired bone growth)
- Pregnancy & breastfeeding (risk of fetal bone/teeth damage)
- Known hypersensitivity to tetracyclines
Cautions:
- Esophageal irritation – take with plenty of water and remain upright for 30 min
- Avoid with antacids, iron, calcium, magnesium (reduce absorption)
- Photosensitivity – advise patients to avoid excessive sunlight
- May cause diarrhea due to alteration of gut flora
Adverse effects:
- GI upset (nausea, vomiting, diarrhea)
- Esophagitis, gastritis
- Photosensitivity rash
- Tooth discoloration (children)
- Rare: hepatotoxicity, intracranial hypertension
📦 Common Packaging:
- Blister packs of 10 or 15 capsules
- Hospital bulk packs
❄️ Storage Conditions:
- Store at room temperature (<25°C)
- Protect from light & moisture
- Keep out of reach of children