Here’s the structured profile for Co-trimoxazole Tablet 400 mg + 80 mg 👇
💊 Co-trimoxazole Tablet 400 mg (Sulphamethoxazole) + 80 mg (Trimethoprim)
📘 Description:
Co-trimoxazole is a fixed-dose combination antibacterial agent containing:
- Sulphamethoxazole (A) – 400 mg (a sulfonamide)
- Trimethoprim (B) – 80 mg (a dihydrofolate reductase inhibitor)
The combination acts synergistically by sequentially blocking folic acid synthesis in bacteria, leading to enhanced antibacterial activity.
📄 Prescription / Indications:
- Respiratory tract infections (bronchitis, pneumonia, including Pneumocystis jirovecii pneumonia)
- Urinary tract infections (UTIs)
- Gastrointestinal infections (shigellosis, traveler’s diarrhea, cholera, typhoid fever)
- Ear, nose & throat infections (otitis media, sinusitis)
- Skin & soft tissue infections (including MRSA in some regions)
- Prophylaxis & treatment of opportunistic infections in immunocompromised patients (esp. HIV/AIDS)
🌿 Nature / Drug Class:
- Antibacterial combination
- Sulfonamide + Diaminopyrimidine
- Bactericidal (synergistic effect)
✅ Advantages:
- Broad-spectrum coverage against Gram-positive & Gram-negative bacteria
- Synergistic action → reduces risk of resistance
- Useful in community-acquired respiratory & urinary infections
- Effective in Pneumocystis jirovecii pneumonia (PCP)
⚠️ Precautions:
- Contraindicated in sulfonamide or trimethoprim hypersensitivity
- Avoid in infants <2 months, pregnancy (esp. 1st trimester, near term), and breastfeeding
- Caution in renal or hepatic impairment
- Monitor complete blood count (CBC) during prolonged use → risk of bone marrow suppression
- Common side effects: nausea, vomiting, rash, pruritus
- Serious but rare: Stevens-Johnson syndrome, toxic epidermal necrolysis, blood dyscrasias
- Ensure adequate hydration to prevent crystalluria
📦 Common Packaging:
- Blister strips or bottles
- Typical pack: 10 tablets / 100 tablets
❄️ Storage Conditions:
- Store at room temperature (<25°C)
- Protect from light and moisture
- Keep out of reach of children