Primaquine Tablet 7.5 mg

💊 Primaquine Tablet 7.5 mg

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📌 Description:

1. Primaquine is an oral antimalarial agent used for radical cure and transmission control of malaria.
2. Each tablet contains 7.5 mg of primaquine phosphate, equivalent to approximately 6.6 mg of primaquine base.
3. It is primarily active against the liver stages (hypnozoites) of P. vivax and P. ovale.
4. Appears as small, film-coated tablets, usually light in color.
5. It is used after initial blood-stage treatment to prevent relapse and block transmission.

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🧪 Nature:

1. Belongs to the 8-aminoquinoline class of antimalarial drugs.
2. Acts as a tissue schizonticide, eliminating liver-stage parasites.
3. Also has gametocytocidal activity, especially effective against P. falciparum gametocytes.
4. Undergoes hepatic metabolism, with metabolites responsible for therapeutic and toxic effects.
5. Active against latent liver forms, making it unique among antimalarials.

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💡 Advantages:

1. Provides radical cure of P. vivax and P. ovale malaria by eradicating hypnozoites.
2. Effective in interrupting malaria transmission by targeting gametocytes.
3. Lower dose formulation (7.5 mg) allows dose flexibility for weight-based pediatric or G6PD-modified regimens.
4. Used in malaria elimination strategies by national and global health programs.
5. May be administered in combination with other antimalarials, such as chloroquine or ACTs.

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💊 Uses:

1. Treatment of relapsing malaria due to Plasmodium vivax and Plasmodium ovale.
2. Transmission-blocking therapy for P. falciparum by killing circulating gametocytes.
3. Can be used in G6PD-normal children at weight-based dosing.
4. May be prescribed for malaria prophylaxis in select geographic regions.
5. Occasionally explored in off-label research for treatment of certain protozoal infections.

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🏥 Storage:

1. Store below 25°C, in a dry, cool place, away from direct sunlight.
2. Protect from moisture and avoid storing in humid areas like bathrooms.
3. Keep tablets in their original blister or bottle packaging until use.
4. Keep out of reach of children, as accidental ingestion may cause serious harm.
5. Do not use beyond the expiry date; safely dispose of unused medicine.