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๐ Description:
- Quinine is an alkaloid compound obtained from the bark of the Cinchona tree.
- It is commonly used in tablet form for the treatment of malaria caused by Plasmodium falciparum.
- Each tablet contains 300 mg of quinine sulfate or quinine hydrochloride, depending on the formulation.
- It works by disrupting the parasite’s ability to break down and metabolize hemoglobin inside red blood cells.
- Quinine tablets are usually white, film-coated, and bitter-tasting.
๐งช Nature:
- Belongs to the class of cinchona alkaloids and antimalarial agents.
- Available in solid oral dosage form; often tablets or capsules.
- Exhibits a bitter taste, characteristic of natural quinoline derivatives.
- Has antimalarial, analgesic, and antipyretic properties.
- It is partially water-soluble and undergoes hepatic metabolism.
๐ก Advantages:
- Convenient oral route of administration for uncomplicated malaria.
- Effective against chloroquine-resistant P. falciparum malaria.
- Useful in combination therapy with doxycycline, clindamycin, or tetracycline.
- Available in many malaria-endemic countries at an affordable price.
- Can be used in pregnancy (Category C) when no safer alternatives are available.
๐ Uses:
- Treatment of uncomplicated malaria due to P. falciparum.
- Used as part of combination regimens to prevent resistance.
- Occasionally used for nocturnal leg cramps (though not commonly recommended now).
- Treatment of relapse or resistant malaria cases.
- Sometimes used as a second-line antimalarial agent in certain countries.
๐ฅ Storage:
- Store at controlled room temperature, between 15โ25ยฐC (59โ77ยฐF).
- Keep in a dry place, away from moisture and humidity.
- Protect from light exposure and direct sunlight.
- Store in original packaging to prevent contamination or degradation.
- Keep out of reach of children and only dispense with a valid prescription.
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