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📌 Tenofovir Disoproxil Fumarate (TDF) Tablet 300 mg
💊 Description:
- TDF is a nucleotide reverse transcriptase inhibitor (NRTI) used in HIV and HBV therapy.
- Each tablet contains 300 mg of tenofovir disoproxil fumarate, equivalent to about 245 mg of tenofovir disoproxil.
- It’s commonly available as a blue or white film-coated tablet.
- It is a prodrug, which converts to tenofovir in the body and inhibits viral replication.
- TDF is often included in fixed-dose combinations with other antiretrovirals.
🌿 Nature:
- Chemically, TDF is an oral prodrug of tenofovir, a nucleotide analogue of adenosine monophosphate.
- It has high oral bioavailability and is rapidly absorbed and converted into its active form.
- TDF targets HIV reverse transcriptase and HBV polymerase enzymes.
- It is a long-acting antiviral with once-daily dosing.
- TDF is water-soluble and usually well tolerated in most patients.
✅ Advantages:
- Effective antiviral activity against both HIV and hepatitis B viruses.
- Once-daily dosing increases patient compliance.
- Used widely due to extensive clinical experience and affordability.
- Included in many first-line ART regimens globally.
- Available as generic formulations, making it accessible in resource-limited settings.
🩺 Uses:
- Treatment of HIV-1 infection in combination with other antiretroviral agents.
- Management of chronic hepatitis B in both adults and adolescents.
- Used in pre-exposure prophylaxis (PrEP) when combined with emtricitabine.
- Suitable for co-infected HIV/HBV patients.
- Sometimes used off-label in post-exposure prophylaxis (PEP) regimens.
❄️ Storage:
- Store at 20°C to 25°C (68°F to 77°F), in a cool and dry place.
- Protect from light and moisture.
- Keep in the original bottle with the desiccant to maintain stability.
- Do not use the tablet if it is discolored or broken.
- Keep away from children, and check expiry before administration.
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