Sofosbuvir Tablet 400 mg

📌 Sofosbuvir Tablet 400 mg

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💊 Description:

1. Sofosbuvir 400 mg is a direct-acting antiviral (DAA) used to treat chronic hepatitis C virus (HCV) infection.
2. It belongs to the nucleotide polymerase inhibitor class and targets the HCV NS5B RNA-dependent RNA polymerase.
3. The tablet is film-coated and usually light yellow or orange in color, intended for oral use.
4. Each tablet contains 400 mg of sofosbuvir as the active ingredient, along with inactive excipients.
5. It is typically used in combination with other antivirals such as ledipasvir, daclatasvir, or ribavirin.

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🌿 Nature:

1. Sofosbuvir is a prodrug that undergoes intracellular conversion to the active triphosphate form.
2. It inhibits viral replication by causing chain termination during RNA synthesis.
3. It is highly specific for the hepatitis C virus and has minimal effects on human DNA or RNA polymerases.
4. It is not effective as monotherapy and must be used in combination regimens.
5. Sofosbuvir is well absorbed orally, with peak plasma levels achieved within 0.5 to 2 hours.

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✅ Advantages:

1. Offers high cure rates (SVR >90%) for many HCV genotypes when used in combination therapy.
2. Can be used in interferon-free regimens, reducing side effects.
3. Allows for shorter treatment durations (often 12–24 weeks).
4. Better tolerability and safety profile compared to older HCV therapies.
5. Has pan-genotypic activity, especially when used with daclatasvir or velpatasvir.

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🩺 Uses:

1. Used for the treatment of chronic HCV infection, particularly genotypes 1–6.
2. Combined with daclatasvir, ledipasvir, velpatasvir, or ribavirin depending on genotype and patient condition.
3. Suitable for use in patients co-infected with HIV.
4. Can be used in patients with compensated liver disease or cirrhosis.
5. Also used in post-liver transplant patients to prevent HCV recurrence.

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❄️ Storage:

1. Store the tablets at 20°C to 25°C (68°F to 77°F); excursions permitted between 15°C and 30°C.
2. Keep the container tightly closed to protect from moisture.
3. Do not refrigerate or freeze; store in a cool, dry place.
4. Protect from light and excessive heat.
5. Keep out of reach of children and do not use after the expiration date.