Entecavir Oral liquid 0.05 mg/mL (p)

📌 Entecavir Oral Liquid 0.05 mg/mL (p)

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💊 Description:

1. Entecavir Oral Liquid 0.05 mg/mL is an oral antiviral formulation for pediatric or swallowing-impaired patients.
2. It is designed to treat chronic hepatitis B virus (HBV) infection by inhibiting viral replication.
3. The liquid form ensures accurate dosing in children and small-dose requirements.
4. It is colorless to slightly yellow and has a palatable flavor for ease of administration.
5. The solution offers bioavailability comparable to the tablet formulation when taken on an empty stomach.

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🌿 Nature:

1. It is a nucleoside analogue reverse transcriptase inhibitor (NRTI) targeting HBV polymerase.
2. The oral solution is specially formulated for precise pediatric dosing based on body weight.
3. It mimics the guanosine nucleoside to interfere with viral DNA synthesis.
4. Stable under room temperature, it does not require reconstitution before use.
5. The preparation may include sweeteners or preservatives to improve shelf-life and palatability.

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✅ Advantages:

1. Enables flexible and accurate dosing, especially in children under 2 years.
2. Avoids issues related to tablet swallowing, helpful for pediatric and elderly patients.
3. Maintains high potency against HBV, including wild-type and some resistant strains.
4. The liquid formulation allows for dose titration based on body surface area or weight.
5. Offers once-daily convenience and is well tolerated during long-term use.

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🩺 Uses:

1. Treatment of chronic hepatitis B infection in children aged ≥2 years.
2. Indicated in pediatric patients with evidence of active viral replication and liver inflammation.
3. Also used in HBV patients with cirrhosis, when oral tablets are unsuitable.
4. Can be prescribed to swallowing-impaired adults as an alternative to tablets.
5. May be used for HBV prophylaxis in immunocompromised patients under pediatric care.

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❄️ Storage:

1. Store at room temperature (20–25°C); avoid freezing.
2. Protect from direct sunlight and heat exposure.
3. Keep the bottle tightly closed and use the measuring device provided.
4. Once opened, the oral liquid is usually stable for up to 30 days (check label).
5. Keep out of reach of children and discard unused solution safely after expiry.