Here is the detailed information for:
💉 Meropenem 1000 mg (as trihydrate) – Powder for Injection
📘 Description:
Meropenem is a carbapenem antibiotic provided as a sterile lyophilized powder for intravenous (IV) use. This dosage strength contains 1000 mg (1 g) of meropenem as the trihydrate.
💊 Prescription / Indications:
Indicated for the treatment of moderate to severe infections, including:
- Hospital-acquired pneumonia (HAP) / Ventilator-associated pneumonia (VAP)
- Intra-abdominal infections
- Bacterial meningitis
- Urinary tract infections (including complicated ones)
- Skin and soft tissue infections
- Septicemia
- Febrile neutropenia (empiric therapy)
- Pelvic infections
- Post-operative infections
🩺 Uses:
- Treats multi-drug resistant Gram-negative and some Gram-positive infections
- Ideal for use in ICU, surgery wards, and sepsis protocols
- Effective against ESBL-producing organisms and anaerobes
🌿 Nature / Drug Class:
- Class: Broad-spectrum carbapenem β-lactam antibiotic
- Bactericidal: Inhibits bacterial cell wall synthesis
- Route: IV infusion or bolus injection
✅ Advantages:
- Very broad coverage: Gram-positive, Gram-negative, and anaerobes
- Resistant to most β-lactamases, including ESBLs
- Crosses the blood-brain barrier – used in meningitis
- Preferred option in life-threatening resistant infections
- Well tolerated even in critically ill patients
⚠️ Precautions:
- Contraindicated in patients with allergy to carbapenems or beta-lactams
- Adjust dose in renal impairment
- Use with caution in:
- Epileptic patients (may provoke seizures)
- Liver dysfunction or hematologic disorders
- Side effects may include:
- Nausea, vomiting, diarrhea
- Injection site reactions
- Seizures (rare), rash, superinfections (e.g., C. difficile)
- Avoid prolonged use to prevent resistance development
📦 Common Packaging:
- Supplied in glass vials with 1000 mg of sterile powder
- For single-dose use only
- Often packed in boxes of 1 or 10 vials for hospital pharmacies
❄️ Storage:
- Store below 25°C in a dry place
- Keep away from light and moisture
- After reconstitution:
- Use immediately or within 6–8 hours if refrigerated (2–8°C)
- Do not freeze the solution
- Use only clear, particle-free solutions