Here is the detailed product information for:
💉 Piperacillin 2000 mg + Tazobactam 250 mg Powder for Injection
📘 Description:
This combination injectable contains:
- Piperacillin (2000 mg) – A broad-spectrum antipseudomonal penicillin
- Tazobactam (250 mg) – A β-lactamase inhibitor that extends the spectrum of piperacillin
Supplied as a sterile powder, it is intended for intravenous (IV) use after reconstitution.
💊 Prescription / Indications:
Indicated in the treatment of moderate to severe infections caused by susceptible organisms:
- Lower respiratory tract infections (e.g. pneumonia)
- Intra-abdominal infections (e.g. appendicitis, peritonitis)
- Skin and soft tissue infections
- Urinary tract infections (UTIs)
- Sepsis and bloodstream infections
- Gynecologic infections
- Febrile neutropenia (empiric therapy)
🩺 Uses:
- Provides broad-spectrum antibacterial coverage, including Pseudomonas aeruginosa
- Used in hospital settings, especially in ICUs
- Often chosen as an empiric therapy when resistant or mixed infections are suspected
🌿 Nature / Drug Class:
- Piperacillin: Ureidopenicillin (β-lactam class)
- Tazobactam: β-lactamase inhibitor
- Route: Intravenous (slow IV push or infusion)
- Mechanism: Inhibits bacterial cell wall synthesis and neutralizes β-lactamase enzymes
✅ Advantages:
- Active against Gram-positive, Gram-negative, and anaerobic bacteria
- Effective against β-lactamase-producing bacteria
- Used in polymicrobial infections
- Low resistance when used appropriately
- Compatible with combination therapy
⚠️ Precautions:
- Hypersensitivity warning: Avoid if allergic to penicillins or cephalosporins
- Renal dose adjustment may be needed in kidney impairment
- Monitor:
- Renal and liver function
- Electrolytes (especially sodium)
- Blood counts during prolonged therapy
- Can cause C. difficile–associated diarrhea
- Avoid use without proper bacterial indication to prevent resistance
📦 Common Packaging:
- Vial containing 2.25 g of sterile powder:
- Piperacillin 2000 mg
- Tazobactam 250 mg
- Single-dose or multi-pack vials
- Administered after dilution with sterile water or saline for IV infusion
❄️ Storage:
- Store at 15–25°C (room temperature)
- Protect from moisture and light
- After reconstitution:
- Use immediately or refrigerate (2–8°C) and use within 24 hours
- Do not freeze the reconstituted solution