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💉 Ceftazidime Powder for Injection 1000 mg (1 g)
📘 Description:
Ceftazidime 1000 mg is a broad-spectrum, third-generation cephalosporin antibiotic, supplied as a sterile lyophilized powder for intravenous (IV) or intramuscular (IM) use. It is especially effective against Pseudomonas aeruginosa and other resistant Gram-negative organisms.
💊 Prescription / Indications:
Indicated for the treatment of serious infections caused by susceptible bacteria, including:
- Lower respiratory tract infections (e.g. pneumonia, bronchitis)
- Sepsis / septicemia
- Urinary tract infections, including complicated cases
- Meningitis (especially Gram-negative meningitis)
- Skin and soft tissue infections
- Abdominal infections (with metronidazole)
- Bone and joint infections
- Infections in immunocompromised patients (e.g. cancer, HIV, transplant)
🩺 Uses:
- Used in hospital and ICU settings
- Broad coverage against Gram-negative organisms, including Pseudomonas spp.
- Sometimes used in combination with other antibiotics in polymicrobial infections
🌿 Nature:
- Class: Cephalosporin (3rd generation)
- Form: Sterile lyophilized powder
- Route: IV or IM injection
- Action: Bactericidal (kills bacteria by inhibiting cell wall synthesis)
✅ Advantages:
- Strong efficacy against multidrug-resistant Gram-negative pathogens
- Useful for hospital-acquired infections
- Excellent tissue penetration, including CNS
- Can be used in empiric therapy when resistance is suspected
- Compatible with many other drugs in combination therapy
⚠️ Precautions:
- Contraindicated in patients with cephalosporin allergy
- Use cautiously in patients with penicillin allergy (cross-reactivity possible)
- Adjust dose in renal impairment
- Risk of Clostridioides difficile-associated diarrhea (CDAD) with prolonged use
- May cause: rash, nausea, elevated liver enzymes, local injection site reactions
- Rare: seizures (in renal dysfunction), eosinophilia, hemolytic anemia
📦 Common Packaging:
- Supplied in a glass vial containing 1000 mg (1 g) of powder
- Vial is intended for single use after reconstitution
- Often packed in cartons for hospital pharmacy supply
❄️ Storage:
- Store at room temperature (below 25°C)
- Keep away from moisture and direct light
- Once reconstituted:
- Use immediately, or
- If stored in refrigeration (2–8°C), use within the specified time per label
- Do not freeze
- Keep out of reach of children