Here is the detailed overview for:
💉 Benzylpenicillin Powder for Injection – 10,00,000 Units (1 Million Units)
🧪 Nature / Drug Class
- Penicillin G (Benzylpenicillin)
- Short-acting natural penicillin
- Beta-lactam class – bactericidal by inhibiting bacterial cell wall synthesis
🩺 Purpose / Indications
Used for treatment of moderate to severe infections caused by penicillin-sensitive organisms, including:
- Meningitis (bacterial origin)
- Severe pneumonia
- Septicemia
- Syphilis (neurosyphilis)
- Endocarditis
- Diphtheria, tetanus, gas gangrene
- Group B streptococcus prophylaxis in labor
⚙️ Advantages
✔️ Broad-spectrum efficacy for gram-positive and some gram-negative organisms
✔️ Fast-acting when given IV
✔️ Preferred in life-threatening infections
✔️ Low resistance among target pathogens
✔️ WHO Essential Medicine
💊 Dosage & Administration
- Route: Intravenous (IV) or Intramuscular (IM)
- Adults: Typically 1–4 million units every 4–6 hours depending on severity
- Children: 25,000 to 50,000 units/kg every 4–6 hours
- Neonates: Adjust dose based on birth weight and age
- Always reconstitute with sterile water or saline before use
📦 Common Packaging
- Vial containing 1 million (10 lac) units of sterile powder
- Usually supplied in glass vials for single use after reconstitution
⚠️ Patient Advice / Precautions
- Test for penicillin allergy before use
- Adjust dose in renal impairment
- Do not mix in the same syringe or IV line with aminoglycosides
- May require frequent dosing due to short half-life (30–60 mins)
💢 Common Side Effects
- Injection site pain or swelling
- Allergic reactions: rash, urticaria, anaphylaxis
- Rare: Seizures, hypokalemia, thrombocytopenia, neurotoxicity with high doses
🧊 Storage
- Store in a cool, dry place below 25°C
- Protect from light
- Use reconstituted solution immediately or as per manufacturer instructions