Here is the detailed profile for:
💉 Benzathine Benzylpenicillin Powder for Injection – 12,00,000 Units
🧪 Nature / Drug Class
- Long-acting natural penicillin
- Class: Beta-lactam antibiotic
- Bactericidal against susceptible Gram-positive organisms
- Depot preparation for prolonged systemic effect
🩺 Purpose / Indications
Used for treatment and long-term prophylaxis of infections such as:
- Rheumatic fever prophylaxis
- Streptococcal pharyngitis/tonsillitis
- Primary and latent syphilis
- Congenital syphilis (in infants)
- Yaws, Pinta, and Bejel (endemic treponematoses)
- Skin and soft tissue infections, e.g., impetigo
⚙️ Advantages
✔️ Long duration of action (up to 3–4 weeks)
✔️ Less frequent dosing – ideal for prophylaxis
✔️ Improves patient compliance
✔️ No need for daily administration
💊 Dosage & Administration
- Adults: Commonly 1.2 to 2.4 million units IM depending on indication
- Children: Weight-based dosing – typically 6 to 12 lac units IM
- Route: Deep intramuscular only
- Do not inject intravenously or subcutaneously
Reconstitution:
- Reconstitute with 2–3 mL of sterile water for injection
- Shake well until a uniform suspension is formed
📦 Common Packaging
- Glass vial containing 1.2 million units sterile powder
- Supplied with or without sterile water for reconstitution
⚠️ Patient Advice / Precautions
- Avoid if allergic to penicillin
- Perform skin test in patients with prior beta-lactam allergy history
- Administer via deep gluteal IM injection to avoid local reaction
- Do not administer IV – can cause cardiopulmonary arrest
- Use caution in renal impairment
- Pregnancy: Generally considered safe (Category B)
💢 Common Side Effects
- Injection site pain, swelling, or redness
- Allergic reactions: urticaria, rash, or rare anaphylaxis
- Serum sickness–like symptoms (rare)
- Local sterile abscess if improper injection technique
🧊 Storage
- Store below 25°C
- Protect from light and moisture
- Use immediately after reconstitution
- Do not freeze