Here is the complete overview for:
💉 Amoxicillin (A) + Clavulanic Acid (B) Powder for Injection
Strength: 500 mg Amoxicillin + 100 mg Clavulanic Acid
Form: Sterile powder for reconstitution (IV/IM injection)
🧪 Nature / Drug Class
- Amoxicillin – Beta-lactam penicillin antibiotic
- Clavulanic Acid – Beta-lactamase inhibitor
- Combined to treat resistant bacterial infections
🩺 Purpose / Indications
Used in moderate to severe infections caused by beta-lactamase–producing organisms:
- Respiratory tract infections (e.g. pneumonia)
- Intra-abdominal infections
- Skin and soft tissue infections
- Bone and joint infections
- Urinary tract infections
- Sepsis and post-surgical infections
⚙️ Advantages
✔️ Broad-spectrum action including beta-lactamase–producing bacteria
✔️ Useful in hospital-acquired infections
✔️ Can be given IV or IM, suitable for inpatient use
✔️ Used when oral therapy is not feasible
💊 Dosage & Administration
- Adult dose: Usually 1.2 g (1000 mg + 200 mg) every 8 hours
(This vial is half of the standard adult dose; can be used for step-down, renal-adjusted, or pediatric use) - Route: Intravenous infusion/slow injection or deep IM
- Reconstitution: Use sterile water for injection
- IV use: Reconstitute and further dilute before slow injection or infusion
- IM use: Reconstitute with compatible solvent for deep injection into muscle
- Dosage adjusted based on age, weight, renal function, and infection severity
📦 Common Packaging
- Glass vial containing sterile powder for injection
- Labeled as 500 mg + 100 mg
- Supplied with or without separate diluent ampoule
⚠️ Patient Advice / Precautions
- Administer under medical supervision
- Monitor for hypersensitivity reactions
- Use caution in patients with penicillin allergy
- Adjust dose in renal impairment
- Complete the course to avoid resistance
💢 Common Side Effects
- Local injection site pain
- Diarrhea, nausea, rash
- Rare:
- Anaphylaxis
- Cholestatic jaundice
- Pseudomembranous colitis
🧊 Storage
- Store vial at temperature below 25°C
- Protect from light and moisture
- Use immediately after reconstitution
- Discard any unused solution