Here is the detailed overview for:
💊 Amoxicillin (A) + Clavulanic Acid (B) Tablet 500 mg (A) + 125 mg (B)
🧪 Nature / Drug Class
🔹 A: Amoxicillin – Beta-lactam antibiotic (aminopenicillin class)
🔹 B: Clavulanic acid – Beta-lactamase inhibitor
🔹 Combined to enhance spectrum and resistance protection
🩺 Purpose / Indications
Used to treat moderate to severe bacterial infections, especially those resistant to amoxicillin alone:
- Respiratory tract infections (e.g., sinusitis, bronchitis, pneumonia)
- Otitis media
- Urinary tract infections
- Skin and soft tissue infections
- Dental infections
- Bone and joint infections
⚙️ Advantages
✔️ Clavulanic acid protects amoxicillin from beta-lactamase enzymes
✔️ Broader activity against resistant organisms
✔️ Effective against mixed aerobic-anaerobic infections
✔️ Suitable for both community-acquired and hospital-acquired infections
💊 Dosage & Administration
- Typical Adult Dose:
- 1 tablet (500/125 mg) every 8–12 hours depending on infection severity
- Take at start of a meal to enhance absorption and reduce gastric irritation
- Adjust dose in renal impairment
📦 Common Packaging
- Strip/blister pack
- Each film-coated tablet contains:
- Amoxicillin trihydrate 500 mg
- Clavulanic acid 125 mg (as potassium clavulanate)
⚠️ Patient Advice / Precautions
- Inform doctor of any penicillin allergy
- Take full course even if symptoms improve early
- May cause diarrhea – report if severe or persistent
- Use cautiously in patients with liver dysfunction or renal impairment
- Ensure proper hydration
💢 Common Side Effects
- Gastrointestinal: Nausea, vomiting, diarrhea
- Skin: Rash, itching
- Rare:
- Hepatic dysfunction (elevated liver enzymes)
- Allergic reactions, anaphylaxis
- Candidiasis (oral or vaginal)
🧊 Storage
- Store below 25°C, in a dry place
- Protect from moisture and light
- Keep out of reach of children