Here is the detailed overview for:
💉 Pentamidine Powder for Injection 200 mg
🧪 Nature / Drug Class
🔹 Antiprotozoal and antifungal agent
🔹 Belongs to the aromatic diamidines class
🔹 Used parenterally (IV or IM)
🩺 Purpose / Indications
✅ Treatment and prophylaxis of:
- Pneumocystis jirovecii pneumonia (PCP) — in immunocompromised patients (e.g., HIV/AIDS)
- Visceral leishmaniasis (kala-azar)
- Trypanosomiasis (early-stage African sleeping sickness)
✅ Alternative to cotrimoxazole in PCP
⚙️ Advantages
✔️ Effective where oral therapy not suitable
✔️ Option for patients intolerant to first-line drugs
✔️ Used in both treatment and prevention of opportunistic infections in HIV
📦 Common Packaging
📦 Supplied as lyophilized powder, 200 mg per vial
💉 To be reconstituted with sterile water
🧪 Administered via slow IV infusion or deep IM injection
⚠️ Patient Advice / Precautions
🧪 Requires monitoring of blood glucose, renal and liver function
⚠️ Watch for hypotension, electrolyte imbalances, renal toxicity
🩺 Administer only under medical supervision
💧 Ensure adequate hydration
🧴 Use within recommended time after reconstitution
🚫 Contraindications / Cautions
❌ Hypersensitivity to pentamidine
⚠️ Use with caution in:
- Renal or hepatic impairment
- Diabetic or pre-diabetic patients (can cause hypoglycemia/hyperglycemia)
- Cardiac disease (may prolong QT interval)
🧊 Storage
🧊 Store powder below 25°C
🌫 Protect from moisture
💉 After reconstitution:
- Use immediately or as per manufacturer’s instructions
- Do not freeze reconstituted solution