Here is a detailed overview of Ganciclovir Powder for Injection 500 mg, with icons:
💉 Ganciclovir Powder for Injection 500 mg
🧪 Nature / Drug Class
🔹 Antiviral
🔹 Nucleoside analogue of guanosine
🔹 Inhibits viral DNA polymerase → prevents viral replication
🔹 Active against cytomegalovirus (CMV) and other herpesviruses
🩺 Purpose / Indications
✅ Used in the treatment and prevention of:
- 🦠 CMV retinitis in immunocompromised individuals (e.g. AIDS)
- 🛡️ Prevention of CMV infection in solid organ and bone marrow transplant recipients
- 🧠 CMV encephalitis, pneumonitis, colitis (in advanced cases)
⚙️ Advantages
✔️ Rapid onset due to IV delivery
✔️ High systemic availability for serious CMV infections
✔️ Standard induction therapy for severe or sight-threatening CMV disease
✔️ Often followed by oral maintenance therapy (ganciclovir or valganciclovir)
📦 Common Packaging
📦 Vial containing 500 mg of ganciclovir (as lyophilized powder)
💧 To be reconstituted with sterile water before IV use
💉 Typically administered as slow IV infusion over 1 hour
⚠️ Patient Advice / Precautions
🩸 Requires regular monitoring of:
- CBC (neutropenia, anemia, thrombocytopenia)
- Renal function (adjust dose in renal impairment)
📛 Use appropriate protective equipment during preparation – hazardous if inhaled/touched
🧪 Ensure hydration during treatment to prevent renal toxicity
🚫 Not for IM or IV bolus injection (may cause severe irritation)
🚫 Contraindications / Cautions
❌ Hypersensitivity to ganciclovir or valganciclovir
⚠️ Caution in:
- Pregnancy (teratogenic; avoid unless life-threatening infection)
- Lactation – excretion in breast milk possible
- Pre-existing bone marrow suppression or renal disease
🧊 Storage
🌡️ Store below 25°C (room temperature) before reconstitution
💉 After reconstitution:
- Use within 12 hours at room temp (not refrigerated)
- Discard any unused portion
🔐 Use safety protocols for cytotoxic drug handling