Here is the detailed overview of Rifabutin Capsule 150 mg, with icons:
💊 Rifabutin Capsule 150 mg
🧪 Nature / Drug Class
🔹 Rifamycin class antibiotic
🔹 Antimycobacterial agent
🔹 Related to rifampicin, but with a longer half-life
🔹 Active against Mycobacterium tuberculosis and Mycobacterium avium complex (MAC)
🩺 Purpose / Indications
✅ Used in treatment and prevention of:
- 🧫 Tuberculosis (TB), especially in patients with HIV
- 💊 MAC infections in immunocompromised individuals (esp. HIV/AIDS)
- 🛑 Alternative to rifampicin when drug interactions are a concern
- 👥 Often used in combination therapy for TB
⚙️ Advantages
✔️ Fewer drug interactions than rifampicin (esp. with antiretrovirals)
✔️ Longer half-life = potential for less frequent dosing
✔️ Effective in HIV-TB co-infected patients
✔️ Useful in rifampicin-resistant TB
📦 Common Packaging
📦 Capsule containing 150 mg rifabutin
🟤 Usually available in blister packs or bottles
⚠️ Patient Advice / Precautions
🧪 Monitor for:
- Liver function tests (LFTs)
- Neutrophil counts (can cause neutropenia)
👁️ Can cause uveitis (eye inflammation), especially when combined with clarithromycin
🧻 May cause orange discoloration of urine, sweat, and tears
📋 Inform doctor if on HIV medications due to interaction potential
⚖️ Dose adjustments may be needed in renal or hepatic impairment
🚫 Contraindications / Cautions
❌ Hypersensitivity to rifamycins
⚠️ Caution in:
- Patients with liver disease
- Concurrent use of CYP450 inhibitors or inducers
- Patients with blood disorders or eye problems
🧊 Storage
🌡️ Store at 15–25°C (room temperature)
🚫 Protect from light and moisture