Ifosfamide Powder for Injection 2000 mg

💊 DESCRIPTION

Ifosfamide is a cytotoxic chemotherapy drug classified as an alkylating agent. It is supplied as a sterile lyophilized powder in a vial and must be reconstituted and diluted for intravenous (IV) infusion.

  • Form: Powder for Injection
  • Strength: 2000 mg per vial
  • Route: Intravenous infusion
  • Drug Class: Nitrogen mustard derivative (alkylating agent)
  • Indications:
    • Testicular cancer (often in combination therapy)
    • Sarcomas (soft tissue and osteogenic)
    • Lymphomas
    • Ovarian cancer
    • Cervical and lung cancers
    • Off-label in certain resistant tumors

ADVANTAGES

  • Effective against a wide range of solid and hematologic tumors
  • Used in high-dose regimens with stem cell rescue
  • Compatible with multiple chemotherapeutic agents for combination regimens
  • Ability to overcome resistance in certain cancers
  • Provides better tumor penetration due to lipophilic properties

🌿 NATURE

  • Mechanism of Action:
    • Ifosfamide is metabolized by the liver into active compounds (e.g., isophosphoramide mustard)
    • These create DNA cross-links, leading to cell cycle arrest and apoptosis
    • It is non–cell-cycle-specific, acting on both dividing and non-dividing cells
  • Closely related to: Cyclophosphamide, but requires higher doses for effect

⚠️ PRECAUTIONS

  • Bone Marrow Suppression: Common; monitor CBC regularly
  • Hemorrhagic Cystitis: Caused by acrolein – always administer mesna and hydration
  • Neurotoxicity: May cause encephalopathy (confusion, hallucinations, somnolence)
  • Nephrotoxicity: Monitor kidney function (especially in pediatric patients)
  • Hepatotoxicity: Rare; monitor liver function tests
  • Nausea/Vomiting: High emetogenic potential – premedicate with antiemetics
  • Fertility Risks: May cause infertility in both genders
  • Pregnancy Category D: Teratogenic – contraindicated in pregnancy and breastfeeding
  • Secondary Cancers: Risk increases with long-term use

🧊 STORAGE

  • Before Reconstitution:
    • Store below 25°C (77°F)
    • Keep in original packaging, protected from light
  • After Reconstitution:
    • Reconstituted solution must be used promptly
    • If diluted, may be stored up to 24 hours at 2–8°C
    • Do not freeze
    • Handle using cytotoxic precautions

👨‍⚕️ PATIENT ADVICE

  • Drink plenty of fluids during and after therapy
  • You will receive mesna to protect your bladder and reduce side effects
  • Report immediately: blood in urine, confusion, excessive drowsiness, fever, mouth sores
  • Avoid pregnancy during and for several months after treatment
  • Hair loss, nausea, fatigue are common and usually temporary
  • Attend all scheduled blood tests to monitor for low blood counts and organ effects
  • Practice good hygiene to avoid infections due to lowered immunity
  • Inform your doctor about all other medications you’re taking

📦 PACKAGING

  • Primary Packaging:
    • Sterile Type I clear glass vial
    • Contains 2000 mg lyophilized powder
    • Sealed with rubber stopper and aluminum/plastic flip-off cap
  • Label Includes:
    • Drug name, strength (2000 mg), batch number, expiry, storage details
  • Secondary Packaging:
    • Individual box with product insert
    • Clearly labeled “Cytotoxic – Handle with care”

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