Here is the detailed overview of Kanamycin Powder for Injection 500 mg, with icons:
💉 Kanamycin Powder for Injection 500 mg
🧪 Nature / Drug Class
🔹 Aminoglycoside antibiotic
🔹 Bactericidal – inhibits protein synthesis
🔹 Second-line anti-tuberculosis drug
🔹 Active against gram-negative bacteria and Mycobacterium tuberculosis
🩺 Purpose / Indications
✅ Used for:
- 🧫 Multidrug-resistant tuberculosis (MDR-TB)
- 💊 Part of DOTS-Plus regimen
- 🦠 Infections caused by gram-negative bacilli (e.g., E. coli, Klebsiella)
- 🏥 Hospital-acquired infections, where culture sensitivity allows
⚙️ Advantages
✔️ Effective where first-line TB drugs fail
✔️ Good penetration in tissues and pleural fluid
✔️ Can be used in combination with other anti-TB agents
✔️ Well established in TB control programs
📦 Common Packaging
📦 Glass vial containing 500 mg sterile powder
💧 Reconstituted with sterile water
💉 For intramuscular (IM) or slow intravenous (IV) administration
⚠️ Patient Advice / Precautions
🦻 Monitor for ototoxicity: hearing loss, vertigo, tinnitus
🧪 Regular labs recommended:
- Serum creatinine / renal function
- Audiometry (baseline + regular)
💧 Ensure proper hydration
⏱️ Administer at regular intervals (typically once daily in TB treatment)
🚫 Avoid mixing in the same syringe with other medications
🚫 Contraindications / Cautions
❌ Allergy to aminoglycosides
⚠️ Use with caution in:
- Patients with renal impairment
- Those on other nephrotoxic drugs (e.g., vancomycin, amphotericin B)
- Patients with myasthenia gravis (may worsen muscle weakness)
🧊 Storage
🌡️ Store vials at 15–25°C (room temperature)
🧪 Use reconstituted solution immediately or store at 2–8°C and use within 24 hours
💡 Protect from light and moisture