💉 Midazolam Injection 5 mg/mL
📌 1. Prescription / Indications:
Midazolam 5 mg/mL Injection is a short-acting benzodiazepine used in:
- Sedation before diagnostic or minor surgical procedures
- Preoperative anxiolysis
- Induction and maintenance of anesthesia
- Status epilepticus (emergency seizure management)
- ICU sedation in ventilated patients
📄 2. Description:
- Form: Sterile, clear, colorless to pale yellow solution
- Strength: 5 mg of Midazolam per 1 mL
- Available volumes: 1 mL, 2 mL, 5 mL, or 10 mL ampoules or vials
- Routes of Administration:
- Intravenous (IV)
- Intramuscular (IM)
- Buccal or rectal (off-label emergency use)
🔬 3. Nature / Drug Class:
- Therapeutic Class: Benzodiazepine
- Mechanism of Action: Enhances GABA activity at GABA-A receptors → CNS depression, causing:
- Sedation
- Anxiolysis
- Muscle relaxation
- Anticonvulsant effects
- Amnesia
🌟 4. Advantages:
- Higher concentration allows reduced volume for injection
- Rapid onset and short duration of action
- Suitable for emergency and ICU use
- Multiple administration routes
- Water-soluble (less vein irritation than diazepam)
📦 5. Common Packaging:
| Packaging | Contents |
|---|
| Glass ampoule | 5 mg/mL in 1 or 2 mL units |
| Single-use vial | 5 mg/mL × 5 or 10 mL |
| Multidose vial (preserved) | 10–50 mL |
🧊 6. Storage Conditions:
- Store at 15–30°C (59–86°F)
- Protect from light and heat
- Do not freeze
- Single-use vials: Discard after opening
- Check for clarity and color before use
👩⚕️ 7. Patient Advice:
- Causes drowsiness, memory loss, confusion — rest and avoid activities like driving
- Tell your provider if you have:
- Liver or kidney impairment
- Sleep apnea or respiratory illness
- History of substance use
- Avoid alcohol, opioids, or other sedatives post-injection
- Only to be used under medical supervision
🎯 8. Purpose / Clinical Use:
| Clinical Context | Use |
|---|
| Emergency seizure control | Status epilepticus |
| Procedural sedation | Endoscopy, cardioversion, dental |
| Pre-anesthesia | Premedication |
| ICU sedation | Ventilated patients |
| Minor surgery or diagnostic | Conscious sedation |
⚠️ 9. Warnings / Precautions:
- Respiratory depression risk — close monitoring required
- Risk increases with opioids, elderly, or chronic illnesses
- Paradoxical effects (agitation, restlessness) are rare but possible
- Titrate dose individually
- Antidote for overdose: Flumazenil
