Here is the detailed overview of:
💊 Delamanid Tablet 50 mg
🌿 Nature / Drug Class:
- Delamanid is an anti-tuberculosis antibiotic
- Belongs to the diarylquinoline derivative class
- Used specifically for multidrug-resistant tuberculosis (MDR-TB)
- Acts by inhibiting mycolic acid synthesis, essential for Mycobacterium tuberculosis cell wall integrity
🎯 Purpose / Indications:
- Used only in combination with other second-line drugs for:
- Multidrug-resistant TB (MDR-TB)
- Extensively drug-resistant TB (XDR-TB)
- Not used for drug-sensitive TB
✅ Advantages:
- Effective against drug-resistant TB strains
- Helps in faster sputum culture conversion
- Improves treatment success rate in MDR/XDR-TB
- Can be used in children over 6 years old (with specialist advice)
💊 Dosage (Adults):
- Weeks 1–8: 100 mg twice daily (i.e., 2 × 50 mg tablets, twice a day)
- Weeks 9–24: 100 mg once daily (i.e., 2 tablets once daily)
Should be taken with food to improve absorption
Always part of a combination MDR-TB regimen
📦 Common Packaging:
- 50 mg tablets
- Blister strips in boxes (often distributed through national TB programs)
⚠️ Precautions / Monitoring:
- Always taken under medical supervision (e.g., under NTEP in India)
- Requires:
- ECG monitoring (risk of QT interval prolongation)
- Liver function tests (LFTs)
- Electrolytes (Potassium, Magnesium)
- Caution with:
- Other QT-prolonging drugs (like bedaquiline)
- Liver disease
- HIV-TB co-infection – check for drug interactions
❌ Contraindications / Use with Caution In:
- Congenital long QT syndrome
- Severe liver impairment
- Children under 6 years (unless clearly indicated)
- Pregnant or breastfeeding women – safety data limited
❗ Possible Side Effects:
- QT prolongation (heart rhythm abnormality – serious risk)
- Nausea, vomiting, abdominal pain
- Dizziness, headache
- Hepatitis or liver enzyme elevation
- Rash or allergic reactions
🧊 Storage:
- Store at room temperature (below 30°C)
- Keep away from light and moisture
- Do not remove tablets from blister until use
📝 Patient Advice:
- Take exactly as prescribed – part of a strict TB regimen
- Do not skip or stop without doctor’s advice
- Eat before taking to reduce stomach upset and improve absorption
- Report immediately if experiencing chest pain, palpitations, or dizziness