💊 Levetiracetam Tablet 750 mg
📌 1. Prescription / Indication:
Levetiracetam 750 mg is used as a prescription antiepileptic drug (AED) to treat:
- Partial-onset seizures (in patients aged ≥4 years)
- Myoclonic seizures (in patients aged ≥12 years with juvenile myoclonic epilepsy)
- Generalized tonic-clonic seizures (in patients aged ≥6 years)
It can be used as monotherapy or adjunctive therapy depending on the condition.
📄 2. Description:
- Form: Film-coated tablet
- Strength: 750 mg
- Color/Shape: Typically blue or light purple, oblong tablets (may vary by brand)
- Route: Oral
- Pharmacokinetics:
- Rapidly absorbed
- Peak plasma concentration: ~1 hour
- Half-life: 6–8 hours
- Renally excreted (minimal liver metabolism)
🔬 3. Nature / Class:
- Drug Class: Antiepileptic / Anticonvulsant
- Mechanism of Action:
Binds to SV2A (synaptic vesicle protein 2A), modulating neurotransmitter release and stabilizing abnormal brain electrical activity.
🌟 4. Advantages:
- Effective against various seizure types
- Minimal drug interactions (not a CYP450 substrate)
- Well-tolerated in most patients
- Can be used in patients with liver dysfunction
- Can be combined with other antiepileptic drugs
📦 5. Common Packaging:
| Type | Details |
|---|---|
| Blister pack | 10 tablets per strip |
| Box | Usually contains 5–10 strips |
| Bottle | Available in some hospitals |
🧊 6. Storage:
- Store at 15°C to 30°C (59–86°F)
- Keep away from moisture, heat, and light
- Keep out of reach of children
- Do not use tablets past their expiration date
👩⚕️ 7. Patient Advice:
- Take exactly as prescribed—usually twice daily
- Can be taken with or without food
- Do not skip or stop suddenly, as this may increase seizure risk
- Report unusual symptoms such as:
- Drowsiness
- Behavioral changes (agitation, depression, aggression)
- Skin rash or allergic reactions
- Avoid alcohol or other CNS depressants
- Dose adjustments may be needed in patients with kidney issues
🎯 8. Purpose / Uses:
| Seizure Type | Use |
|---|---|
| Partial-onset seizures | Monotherapy or adjunct |
| Juvenile myoclonic epilepsy | Adjunctive treatment |
| Generalized tonic-clonic seizures | Adjunctive treatment |
⚠️ 9. Precautions / Warnings:
- Renal impairment: Dose adjustment required
- May cause somnolence, dizziness, or mood changes
- Use cautiously in pregnancy/lactation
- Pediatric and elderly patients may need special monitoring
- Watch for signs of suicidal ideation